Frustrated Lewis Pair-Catalyzed Cycloisomerization of 1,5-Enynes via a 5-endo-dig Cyclization/Protodeborylation Sequence

The first frustrated Lewis pair‐catalyzed cycloisomerization of a series of 1,5‐enynes was developed. The reaction proceeds via the π‐activation of the alkyne and subsequent 5‐endo‐dig cyclization with the adjacent alkene. The presence of PPh3 was of utmost importance on the one hand to prevent side...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-03, Vol.55 (13), p.4336-4339
Hauptverfasser:	Tamke, Sergej, Qu, Zheng-Wang, Sitte, Nikolai A., Flörke, Ulrich, Grimme, Stefan, Paradies, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	1,5-enynes 5-enynes Alkenes Alkynes Catalysis cycloisomerization frustrated Lewis pairs Isomerization kinetic isotope effect Organic chemistry protodeborylation Side reactions
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