Postrelapse Prognostic Factors in Nonmetastatic Osteosarcoma: A Single-institution Experience
The purpose of this study was to analyze the prognostic factors that influence postrelapse survival (PRS) in children and adolescents with initial localized high-grade osteosarcoma. This is a retrospective evaluation of patients aged 21 years and below with nonmetastatic high-grade osteosarcoma trea...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2016-04, Vol.38 (3), p.176-181 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | Berlanga, Pablo Cañete, Adela Salom, Marta Montalar, Joaquin Guasp, Maria Marco, Alfredo Castel, Victoria |
| description | The purpose of this study was to analyze the prognostic factors that influence postrelapse survival (PRS) in children and adolescents with initial localized high-grade osteosarcoma.
This is a retrospective evaluation of patients aged 21 years and below with nonmetastatic high-grade osteosarcoma treated at our institution from 1985 to 2011 who developed recurrent disease after achievement of an initial complete response (CR). PRS and postrelapse event-free survival (PREFS) analyses were performed using the Kaplan-Meier method and log-rank test. Multivariate Cox regression analysis was used to determine which variables were independently prognostic.
Thirty-one patients were included. Median age at primary diagnosis was 13.7 years (range, 1.9 to 21.0 y). Median time to first relapse was 16 months (range, 3 to 36 mo). Fourteen patients achieved a second CR (CR2) after surgery±chemotherapy treatment. The 5-year PRS and PREFS were both 26% (95% confidence interval, 14%-49%), with a median follow-up of 99 months (range, 27 to 271 mo). Multivariate analysis showed that achievement of CR2 (P |
| doi_str_mv | 10.1097/MPH.0000000000000546 |
| format | Article |
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This is a retrospective evaluation of patients aged 21 years and below with nonmetastatic high-grade osteosarcoma treated at our institution from 1985 to 2011 who developed recurrent disease after achievement of an initial complete response (CR). PRS and postrelapse event-free survival (PREFS) analyses were performed using the Kaplan-Meier method and log-rank test. Multivariate Cox regression analysis was used to determine which variables were independently prognostic.
Thirty-one patients were included. Median age at primary diagnosis was 13.7 years (range, 1.9 to 21.0 y). Median time to first relapse was 16 months (range, 3 to 36 mo). Fourteen patients achieved a second CR (CR2) after surgery±chemotherapy treatment. The 5-year PRS and PREFS were both 26% (95% confidence interval, 14%-49%), with a median follow-up of 99 months (range, 27 to 271 mo). Multivariate analysis showed that achievement of CR2 (P<0.001) and histologic response to first-line treatment (P=0.02) were significantly associated with PRS, whereas time to first relapse did not retain univariate significance.
Achievement of CR2 and histologic response to preoperative first-line treatment are independent survival prognostic factors in osteosarcoma recurrence.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/MPH.0000000000000546</identifier><identifier>PMID: 26925713</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bone Neoplasms - mortality ; Bone Neoplasms - pathology ; Bone Neoplasms - therapy ; Chemotherapy, Adjuvant - methods ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Kaplan-Meier Estimate ; Male ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; Osteosarcoma - therapy ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Young Adult</subject><ispartof>Journal of pediatric hematology/oncology, 2016-04, Vol.38 (3), p.176-181</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-fc00c2ea787abbd273905a13cc786ae1d6482df5af15f0f14fb2463b056de3803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26925713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlanga, Pablo</creatorcontrib><creatorcontrib>Cañete, Adela</creatorcontrib><creatorcontrib>Salom, Marta</creatorcontrib><creatorcontrib>Montalar, Joaquin</creatorcontrib><creatorcontrib>Guasp, Maria</creatorcontrib><creatorcontrib>Marco, Alfredo</creatorcontrib><creatorcontrib>Castel, Victoria</creatorcontrib><title>Postrelapse Prognostic Factors in Nonmetastatic Osteosarcoma: A Single-institution Experience</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>The purpose of this study was to analyze the prognostic factors that influence postrelapse survival (PRS) in children and adolescents with initial localized high-grade osteosarcoma.
This is a retrospective evaluation of patients aged 21 years and below with nonmetastatic high-grade osteosarcoma treated at our institution from 1985 to 2011 who developed recurrent disease after achievement of an initial complete response (CR). PRS and postrelapse event-free survival (PREFS) analyses were performed using the Kaplan-Meier method and log-rank test. Multivariate Cox regression analysis was used to determine which variables were independently prognostic.
Thirty-one patients were included. Median age at primary diagnosis was 13.7 years (range, 1.9 to 21.0 y). Median time to first relapse was 16 months (range, 3 to 36 mo). Fourteen patients achieved a second CR (CR2) after surgery±chemotherapy treatment. The 5-year PRS and PREFS were both 26% (95% confidence interval, 14%-49%), with a median follow-up of 99 months (range, 27 to 271 mo). Multivariate analysis showed that achievement of CR2 (P<0.001) and histologic response to first-line treatment (P=0.02) were significantly associated with PRS, whereas time to first relapse did not retain univariate significance.
Achievement of CR2 and histologic response to preoperative first-line treatment are independent survival prognostic factors in osteosarcoma recurrence.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - pathology</subject><subject>Osteosarcoma - therapy</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9LAzEQxYMotla_gcgevWxNNv-23oq0Vqi2oB5lyWZnS2Q3qUkW9Nu7pVXEucwM894b-CF0SfCY4Im8eVwvxvhvcSaO0JBwKlIqZH7cz1jKlBHCBugshHeMiaQsO0WDTEwyLgkdore1C9FDo7YBkrV3G9vvRidzpaPzITE2eXK2hahCVLvDKkRwQXntWnWbTJNnYzcNpMb2tthF42wy-9yCN2A1nKOTWjUBLg59hF7ns5e7Rbpc3T_cTZepzriIaa0x1hkomUtVllUm6QRzRajWMhcKSCVYnlU1VzXhNa4Jq8uMCVpiLiqgOaYjdL3P3Xr30UGIRWuChqZRFlwXCiIl73WM0F7K9lLtXQge6mLrTav8V0FwsQNb9GCL_2B729XhQ1e2UP2afkjSbz90dOQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Berlanga, Pablo</creator><creator>Cañete, Adela</creator><creator>Salom, Marta</creator><creator>Montalar, Joaquin</creator><creator>Guasp, Maria</creator><creator>Marco, Alfredo</creator><creator>Castel, Victoria</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Postrelapse Prognostic Factors in Nonmetastatic Osteosarcoma: A Single-institution Experience</title><author>Berlanga, Pablo ; Cañete, Adela ; Salom, Marta ; Montalar, Joaquin ; Guasp, Maria ; Marco, Alfredo ; Castel, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-fc00c2ea787abbd273905a13cc786ae1d6482df5af15f0f14fb2463b056de3803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - therapy</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - pathology</topic><topic>Osteosarcoma - therapy</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlanga, Pablo</creatorcontrib><creatorcontrib>Cañete, Adela</creatorcontrib><creatorcontrib>Salom, Marta</creatorcontrib><creatorcontrib>Montalar, Joaquin</creatorcontrib><creatorcontrib>Guasp, Maria</creatorcontrib><creatorcontrib>Marco, Alfredo</creatorcontrib><creatorcontrib>Castel, Victoria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlanga, Pablo</au><au>Cañete, Adela</au><au>Salom, Marta</au><au>Montalar, Joaquin</au><au>Guasp, Maria</au><au>Marco, Alfredo</au><au>Castel, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postrelapse Prognostic Factors in Nonmetastatic Osteosarcoma: A Single-institution Experience</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>38</volume><issue>3</issue><spage>176</spage><epage>181</epage><pages>176-181</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><abstract>The purpose of this study was to analyze the prognostic factors that influence postrelapse survival (PRS) in children and adolescents with initial localized high-grade osteosarcoma.
This is a retrospective evaluation of patients aged 21 years and below with nonmetastatic high-grade osteosarcoma treated at our institution from 1985 to 2011 who developed recurrent disease after achievement of an initial complete response (CR). PRS and postrelapse event-free survival (PREFS) analyses were performed using the Kaplan-Meier method and log-rank test. Multivariate Cox regression analysis was used to determine which variables were independently prognostic.
Thirty-one patients were included. Median age at primary diagnosis was 13.7 years (range, 1.9 to 21.0 y). Median time to first relapse was 16 months (range, 3 to 36 mo). Fourteen patients achieved a second CR (CR2) after surgery±chemotherapy treatment. The 5-year PRS and PREFS were both 26% (95% confidence interval, 14%-49%), with a median follow-up of 99 months (range, 27 to 271 mo). Multivariate analysis showed that achievement of CR2 (P<0.001) and histologic response to first-line treatment (P=0.02) were significantly associated with PRS, whereas time to first relapse did not retain univariate significance.
Achievement of CR2 and histologic response to preoperative first-line treatment are independent survival prognostic factors in osteosarcoma recurrence.</abstract><cop>United States</cop><pmid>26925713</pmid><doi>10.1097/MPH.0000000000000546</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Neoplasms - mortality Bone Neoplasms - pathology Bone Neoplasms - therapy Chemotherapy, Adjuvant - methods Child Child, Preschool Disease-Free Survival Female Humans Infant Kaplan-Meier Estimate Male Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Osteosarcoma - mortality Osteosarcoma - pathology Osteosarcoma - therapy Prognosis Proportional Hazards Models Retrospective Studies Young Adult |
| title | Postrelapse Prognostic Factors in Nonmetastatic Osteosarcoma: A Single-institution Experience |
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