Critical considerations for developing nucleic acid macromolecule based drug products

•Increased emphasis in recent years on DNA/mRNA macromolecule-based therapeutic drugs.•Formulation excipients and their role in increasing the drug product stability are discussed.•Chemical liabilities, major degradation routes and characterization methods are reviewed.•Advanced formulations for som...

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Veröffentlicht in:	Drug discovery today 2016-03, Vol.21 (3), p.430-444
Hauptverfasser:	Muralidhara, Bilikallahalli K., Baid, Rinku, Bishop, Steve M., Huang, Min, Wang, Wei, Nema, Sandeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Compounding Drug Stability Nucleic Acids - chemistry
Online-Zugang:	Volltext
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