Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation
Ablation for atrial fibrillation (AF) has been suggested to be associated with 'reverse left atrial remodelling'. Reduction in left atrial volume index (LAVIR) is regarded as a determinant of reverse remodelling following pulmonary vein isolation (PVI). However, there is paucity on data ab...
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| Veröffentlicht in: | Europace (London, England) England), 2016-03, Vol.18 (3), p.392-397 |
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| creator | Yalcin, Muhammed Ulvi Gurses, Kadri Murat Kocyigit, Duygu Evranos, Banu Yorgun, Hikmet Sahiner, Levent Kaya, Ergun Baris Oto, Mehmet Ali Aytemir, Kudret Ozer, Necla |
| description | Ablation for atrial fibrillation (AF) has been suggested to be associated with 'reverse left atrial remodelling'. Reduction in left atrial volume index (LAVIR) is regarded as a determinant of reverse remodelling following pulmonary vein isolation (PVI). However, there is paucity on data about the predictors for LAVIR after PVI. In this study, we aimed to investigate predictors of LAVIR at 12 months in AF patients undergoing cryoballoon-based PVI.
Patients with symptomatic paroxysmal or persistent AF despite ≥1 antiarrhythmic drug(s), who were scheduled for cryoballoon-based AF ablation procedure per the recent consensus recommendations, were enrolled and followed-up for 12 months in this prospective observational study. Left atrial volume was derived using the biplane area-length method. A total of 160 patients (54.25 ± 7.66 years, 44.40% female) were involved in the study. Reduction in left atrial volume index occurred in 120 patients. Age [hazard ratio (HR): 0.901, 95% confidence interval (CI): 0.828-0.981, P = 0.017], hypertension (HR: 0.151, 95% CI: 0.048-0.471, P = 0.001), mild mitral regurgitation (MR) (HR: 5.327, 95% CI: 1.489-19.058, P = 0.010), and AF recurrence (HR: 0.017, 95% CI: 0.005-0.065, P< 0.001) were found to be independent predictors for LAVIR.
To the best of our knowledge, this is the largest study in the literature investigating the predictors of LAVIR following AF ablation. According to this data, younger patients without hypertension or moderate MR are most likely to experience LAVIR following ablation. |
| doi_str_mv | 10.1093/europace/euv102 |
| format | Article |
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Patients with symptomatic paroxysmal or persistent AF despite ≥1 antiarrhythmic drug(s), who were scheduled for cryoballoon-based AF ablation procedure per the recent consensus recommendations, were enrolled and followed-up for 12 months in this prospective observational study. Left atrial volume was derived using the biplane area-length method. A total of 160 patients (54.25 ± 7.66 years, 44.40% female) were involved in the study. Reduction in left atrial volume index occurred in 120 patients. Age [hazard ratio (HR): 0.901, 95% confidence interval (CI): 0.828-0.981, P = 0.017], hypertension (HR: 0.151, 95% CI: 0.048-0.471, P = 0.001), mild mitral regurgitation (MR) (HR: 5.327, 95% CI: 1.489-19.058, P = 0.010), and AF recurrence (HR: 0.017, 95% CI: 0.005-0.065, P< 0.001) were found to be independent predictors for LAVIR.
To the best of our knowledge, this is the largest study in the literature investigating the predictors of LAVIR following AF ablation. According to this data, younger patients without hypertension or moderate MR are most likely to experience LAVIR following ablation.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/euv102</identifier><identifier>PMID: 25999187</identifier><language>eng</language><publisher>England</publisher><subject>Age Factors ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Atrial Function, Left ; Atrial Remodeling ; Catheter Ablation - adverse effects ; Catheter Ablation - instrumentation ; Catheter Ablation - methods ; Cryosurgery - adverse effects ; Cryosurgery - instrumentation ; Female ; Heart Atria - physiopathology ; Heart Atria - surgery ; Humans ; Hypertension - complications ; Male ; Middle Aged ; Mitral Valve Insufficiency - complications ; Prospective Studies ; Pulmonary Veins - physiopathology ; Pulmonary Veins - surgery ; Recurrence ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Europace (London, England), 2016-03, Vol.18 (3), p.392-397</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-ff8846bb2f9c40d45ee581e51617d8236577ad8bd7140e788fd086f2366469ed3</citedby><cites>FETCH-LOGICAL-c404t-ff8846bb2f9c40d45ee581e51617d8236577ad8bd7140e788fd086f2366469ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25999187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yalcin, Muhammed Ulvi</creatorcontrib><creatorcontrib>Gurses, Kadri Murat</creatorcontrib><creatorcontrib>Kocyigit, Duygu</creatorcontrib><creatorcontrib>Evranos, Banu</creatorcontrib><creatorcontrib>Yorgun, Hikmet</creatorcontrib><creatorcontrib>Sahiner, Levent</creatorcontrib><creatorcontrib>Kaya, Ergun Baris</creatorcontrib><creatorcontrib>Oto, Mehmet Ali</creatorcontrib><creatorcontrib>Aytemir, Kudret</creatorcontrib><creatorcontrib>Ozer, Necla</creatorcontrib><title>Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>Ablation for atrial fibrillation (AF) has been suggested to be associated with 'reverse left atrial remodelling'. Reduction in left atrial volume index (LAVIR) is regarded as a determinant of reverse remodelling following pulmonary vein isolation (PVI). However, there is paucity on data about the predictors for LAVIR after PVI. In this study, we aimed to investigate predictors of LAVIR at 12 months in AF patients undergoing cryoballoon-based PVI.
Patients with symptomatic paroxysmal or persistent AF despite ≥1 antiarrhythmic drug(s), who were scheduled for cryoballoon-based AF ablation procedure per the recent consensus recommendations, were enrolled and followed-up for 12 months in this prospective observational study. Left atrial volume was derived using the biplane area-length method. A total of 160 patients (54.25 ± 7.66 years, 44.40% female) were involved in the study. Reduction in left atrial volume index occurred in 120 patients. Age [hazard ratio (HR): 0.901, 95% confidence interval (CI): 0.828-0.981, P = 0.017], hypertension (HR: 0.151, 95% CI: 0.048-0.471, P = 0.001), mild mitral regurgitation (MR) (HR: 5.327, 95% CI: 1.489-19.058, P = 0.010), and AF recurrence (HR: 0.017, 95% CI: 0.005-0.065, P< 0.001) were found to be independent predictors for LAVIR.
To the best of our knowledge, this is the largest study in the literature investigating the predictors of LAVIR following AF ablation. According to this data, younger patients without hypertension or moderate MR are most likely to experience LAVIR following ablation.</description><subject>Age Factors</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Atrial Function, Left</subject><subject>Atrial Remodeling</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - instrumentation</subject><subject>Catheter Ablation - methods</subject><subject>Cryosurgery - adverse effects</subject><subject>Cryosurgery - instrumentation</subject><subject>Female</subject><subject>Heart Atria - physiopathology</subject><subject>Heart Atria - surgery</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitral Valve Insufficiency - complications</subject><subject>Prospective Studies</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Pulmonary Veins - surgery</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UD1PwzAQtRCIQmFmQx5ZQm0nju0RVXxJlWCAOXLiMzJy4mInhf57XLUwnO7d3XtPp4fQFSW3lKhyAVMMa91BBhtK2BE6o7xkBSOKHWdMlCo4ZWqGzlP6JIQIpvgpmjGulKJSnCF4jWBcN4aYcLDYgx2xHqPTHm-Cn3rAbjDwgzNr6kYXBmyD9-HbDR-4i9vQ6jyFoWh1AoPXk-_DoOMWb8AN2KXg9U50gU6s9gkuD32O3h_u35ZPxerl8Xl5tyq6ilRjYa2UVd22zKq8MBUH4JICpzUVRrKy5kJoI1sjaEVASGkNkbXNh7qqFZhyjm72vusYviZIY9O71IH3eoAwpYYKwctcNc3UxZ7axZBSBNuso-vz6w0lzS7b5i_bZp9tVlwfzKe2B_PP_wuz_AWh2HpR</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Yalcin, Muhammed Ulvi</creator><creator>Gurses, Kadri Murat</creator><creator>Kocyigit, Duygu</creator><creator>Evranos, Banu</creator><creator>Yorgun, Hikmet</creator><creator>Sahiner, Levent</creator><creator>Kaya, Ergun Baris</creator><creator>Oto, Mehmet Ali</creator><creator>Aytemir, Kudret</creator><creator>Ozer, Necla</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation</title><author>Yalcin, Muhammed Ulvi ; Gurses, Kadri Murat ; Kocyigit, Duygu ; Evranos, Banu ; Yorgun, Hikmet ; Sahiner, Levent ; Kaya, Ergun Baris ; Oto, Mehmet Ali ; Aytemir, Kudret ; Ozer, Necla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-ff8846bb2f9c40d45ee581e51617d8236577ad8bd7140e788fd086f2366469ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Atrial Function, Left</topic><topic>Atrial Remodeling</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - instrumentation</topic><topic>Catheter Ablation - methods</topic><topic>Cryosurgery - adverse effects</topic><topic>Cryosurgery - instrumentation</topic><topic>Female</topic><topic>Heart Atria - physiopathology</topic><topic>Heart Atria - surgery</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitral Valve Insufficiency - complications</topic><topic>Prospective Studies</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Pulmonary Veins - surgery</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yalcin, Muhammed Ulvi</creatorcontrib><creatorcontrib>Gurses, Kadri Murat</creatorcontrib><creatorcontrib>Kocyigit, Duygu</creatorcontrib><creatorcontrib>Evranos, Banu</creatorcontrib><creatorcontrib>Yorgun, Hikmet</creatorcontrib><creatorcontrib>Sahiner, Levent</creatorcontrib><creatorcontrib>Kaya, Ergun Baris</creatorcontrib><creatorcontrib>Oto, Mehmet Ali</creatorcontrib><creatorcontrib>Aytemir, Kudret</creatorcontrib><creatorcontrib>Ozer, Necla</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Europace (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yalcin, Muhammed Ulvi</au><au>Gurses, Kadri Murat</au><au>Kocyigit, Duygu</au><au>Evranos, Banu</au><au>Yorgun, Hikmet</au><au>Sahiner, Levent</au><au>Kaya, Ergun Baris</au><au>Oto, Mehmet Ali</au><au>Aytemir, Kudret</au><au>Ozer, Necla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation</atitle><jtitle>Europace (London, England)</jtitle><addtitle>Europace</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>18</volume><issue>3</issue><spage>392</spage><epage>397</epage><pages>392-397</pages><issn>1099-5129</issn><eissn>1532-2092</eissn><abstract>Ablation for atrial fibrillation (AF) has been suggested to be associated with 'reverse left atrial remodelling'. Reduction in left atrial volume index (LAVIR) is regarded as a determinant of reverse remodelling following pulmonary vein isolation (PVI). However, there is paucity on data about the predictors for LAVIR after PVI. In this study, we aimed to investigate predictors of LAVIR at 12 months in AF patients undergoing cryoballoon-based PVI.
Patients with symptomatic paroxysmal or persistent AF despite ≥1 antiarrhythmic drug(s), who were scheduled for cryoballoon-based AF ablation procedure per the recent consensus recommendations, were enrolled and followed-up for 12 months in this prospective observational study. Left atrial volume was derived using the biplane area-length method. A total of 160 patients (54.25 ± 7.66 years, 44.40% female) were involved in the study. Reduction in left atrial volume index occurred in 120 patients. Age [hazard ratio (HR): 0.901, 95% confidence interval (CI): 0.828-0.981, P = 0.017], hypertension (HR: 0.151, 95% CI: 0.048-0.471, P = 0.001), mild mitral regurgitation (MR) (HR: 5.327, 95% CI: 1.489-19.058, P = 0.010), and AF recurrence (HR: 0.017, 95% CI: 0.005-0.065, P< 0.001) were found to be independent predictors for LAVIR.
To the best of our knowledge, this is the largest study in the literature investigating the predictors of LAVIR following AF ablation. According to this data, younger patients without hypertension or moderate MR are most likely to experience LAVIR following ablation.</abstract><cop>England</cop><pmid>25999187</pmid><doi>10.1093/europace/euv102</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Factors Atrial Fibrillation - diagnosis Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Atrial Function, Left Atrial Remodeling Catheter Ablation - adverse effects Catheter Ablation - instrumentation Catheter Ablation - methods Cryosurgery - adverse effects Cryosurgery - instrumentation Female Heart Atria - physiopathology Heart Atria - surgery Humans Hypertension - complications Male Middle Aged Mitral Valve Insufficiency - complications Prospective Studies Pulmonary Veins - physiopathology Pulmonary Veins - surgery Recurrence Risk Factors Time Factors Treatment Outcome |
| title | Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation |
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