A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1

The protein kinase Chk1 is required in the fission yeast Schizosaccharomyces pombe for delaying cell cycle progression in response to DNA damage. Chk1 becomes phosphorylated when DNA is damaged by a variety of agents, including the anti-tumor drug camptothecin. To further characterize the behavior o...

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Veröffentlicht in:	Current genetics 2001-01, Vol.38 (6), p.299-306
Hauptverfasser:	Wan, S, Walworth, N C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence camptothecin Camptothecin - pharmacology Cell Cycle Proteins Checkpoint Kinase 1 Chk1 protein Conserved Sequence DNA Damage DNA Replication Genes, cdc Genes, Fungal Genotype Hydroxyurea - pharmacology Molecular Sequence Data Mutation Nuclear Proteins Phenotype Phosphorylation Point Mutation - drug effects Protein Kinases - genetics Protein-Tyrosine Kinases - genetics Schizosaccharomyces - genetics Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins Ultraviolet Rays
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