α-Lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis

α-Lipoic acid (α-LA) is a neuroprotective metabolic antioxidant that has been shown to cross the blood brain barrier. We tested whether α-LA is capable to prevent MOG35–55-induced experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). Daily oral administrat...

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Veröffentlicht in:	Journal of neuroimmunology 2004-03, Vol.148 (1), p.146-153
Hauptverfasser:	Morini, Monica, Roccatagliata, Luca, Dell'Eva, Raffaella, Pedemonte, Enrico, Furlan, Roberto, Minghelli, Simona, Giunti, Debora, Pfeffer, Ulrich, Marchese, Monica, Noonan, Douglas, Mancardi, Gianluigi, Albini, Adriana, Uccelli, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anti-oxidant Antioxidants - therapeutic use Cell Line, Tumor Dose-Response Relationship, Drug Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - prevention & control Experimental autoimmune encephalomyelitis Female Fibrosarcoma - drug therapy Glycoproteins Immunization Inflammation Interferon-gamma - metabolism Interleukin-4 - metabolism Invasion Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Multiple sclerosis Mycobacterium tuberculosis Myelin-Oligodendrocyte Glycoprotein Peptide Fragments Spinal Cord - drug effects Spinal Cord - pathology T-Lymphocytes - drug effects Thioctic Acid - therapeutic use
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