E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling
Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are attached to each other in the bone marrow (BM) cavity and in in vitro cultures, and this adhesion has important physiological significance. We demonstrated that cell proliferation could be promoted when MSCs were co‐cultured w...
Gespeichert in:
| Veröffentlicht in: | Cell biology international 2016-04, Vol.40 (4), p.407-418 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 418 |
|---|---|
| container_issue | 4 |
| container_start_page | 407 |
| container_title | Cell biology international |
| container_volume | 40 |
| creator | Xia, Jie Zhang, Hongwei Gao, Xiaopeng Guo, Jun Hou, Jixue Wang, Xiaoyi Wang, Sibo Yang, Tao Zhang, Xuyong Ge, Quanhu Wan, Longfei Cheng, Wenzhe Zheng, Jinpo Chen, Xueling Wu, Xiangwei |
| description | Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are attached to each other in the bone marrow (BM) cavity and in in vitro cultures, and this adhesion has important physiological significance. We demonstrated that cell proliferation could be promoted when MSCs were co‐cultured with EPCs, which was beneficial to angiogenesis, tissue repair, and regeneration. The adhesion of MSCs and EPCs could promote the pluripotency of MSCs, particularly self‐renewal and multi‐differentiation to osteoblasts, chondrocytes, and adipocytes. This study focused on the mechanism of adhesion between EPCs and MSCs. The results showed that E‐cadherin (E‐cad) mediated the adhesion of MSCs and EPCs through the E‐cad/beta‐catenin signaling pathway. The E‐cad of EPCs occupied a dominant position during this process, which activated and up‐regulated the beta‐catenin (β‐catenin) of MSCs to improve cohesion and exert their biological function. |
| doi_str_mv | 10.1002/cbin.10579 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1775177532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1775177532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3529-a41c2e45c86ff98e89f62cde499327557d3f3a361f8456d146bcca05906e4c5d3</originalsourceid><addsrcrecordid>eNp9kNFOHCEUholpo9Z64wMYLhuTaWEYYLhst3bXxKhN2nhJWObMDjrDWGCj-1o-iM9Uprt62QvCSfj-n5MPoRNKPlNCyi926XyeuFR76JASxYuacf5umgUvhFL8AH2I8Y4QSqta7KODUkhJpSSHKJ0X1jQdBOeLARpnEjTYjj4Zm_DYYvDNmDronenxQxhX4F0aA7bQ9xE_utThASJ4222GTMQEw-4tdWFcrzr88pw_SDnmcXQrb3rnVx_R-9b0EY539xH6_eP812xRXF7PL2ZfLwvLeKkKU1FbQsVtLdpW1VCrVpS2gUopVkrOZcNaZpigbV1x0dBKLK01hCsioLK8YUfo07Y3b_5nDTHpwcVpPeNhXEedFfDpsDKjZ1vUhjHGAK1-CG4wYaMp0ZNlPVnW_yxn-HTXu15maW_oq9YM0C3w6HrY_KdKz75dXL2WFtuMyxaf3jIm3GshmeT69mquyeLnjVp8n-sZ-wsbw5kn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1775177532</pqid></control><display><type>article</type><title>E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Xia, Jie ; Zhang, Hongwei ; Gao, Xiaopeng ; Guo, Jun ; Hou, Jixue ; Wang, Xiaoyi ; Wang, Sibo ; Yang, Tao ; Zhang, Xuyong ; Ge, Quanhu ; Wan, Longfei ; Cheng, Wenzhe ; Zheng, Jinpo ; Chen, Xueling ; Wu, Xiangwei</creator><creatorcontrib>Xia, Jie ; Zhang, Hongwei ; Gao, Xiaopeng ; Guo, Jun ; Hou, Jixue ; Wang, Xiaoyi ; Wang, Sibo ; Yang, Tao ; Zhang, Xuyong ; Ge, Quanhu ; Wan, Longfei ; Cheng, Wenzhe ; Zheng, Jinpo ; Chen, Xueling ; Wu, Xiangwei</creatorcontrib><description>Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are attached to each other in the bone marrow (BM) cavity and in in vitro cultures, and this adhesion has important physiological significance. We demonstrated that cell proliferation could be promoted when MSCs were co‐cultured with EPCs, which was beneficial to angiogenesis, tissue repair, and regeneration. The adhesion of MSCs and EPCs could promote the pluripotency of MSCs, particularly self‐renewal and multi‐differentiation to osteoblasts, chondrocytes, and adipocytes. This study focused on the mechanism of adhesion between EPCs and MSCs. The results showed that E‐cadherin (E‐cad) mediated the adhesion of MSCs and EPCs through the E‐cad/beta‐catenin signaling pathway. The E‐cad of EPCs occupied a dominant position during this process, which activated and up‐regulated the beta‐catenin (β‐catenin) of MSCs to improve cohesion and exert their biological function.</description><identifier>ISSN: 1065-6995</identifier><identifier>EISSN: 1095-8355</identifier><identifier>DOI: 10.1002/cbin.10579</identifier><identifier>PMID: 26771770</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>adhesion ; Animals ; beta Catenin - genetics ; beta Catenin - metabolism ; beta-catenin ; Bone Marrow Cells - cytology ; Cadherins - antagonists & inhibitors ; Cadherins - genetics ; Cadherins - metabolism ; Cell Adhesion ; Cell Differentiation ; Cells, Cultured ; Coculture Techniques ; E-cadherin ; Endothelial Progenitor Cells - cytology ; Endothelial Progenitor Cells - metabolism ; Enzyme-Linked Immunosorbent Assay ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence ; Real-Time Polymerase Chain Reaction ; RNA Interference ; RNA, Messenger - metabolism ; RNA, Small Interfering - metabolism ; Signal Transduction ; siRNA ; transfection ; Up-Regulation</subject><ispartof>Cell biology international, 2016-04, Vol.40 (4), p.407-418</ispartof><rights>2016 International Federation for Cell Biology</rights><rights>2016 International Federation for Cell Biology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3529-a41c2e45c86ff98e89f62cde499327557d3f3a361f8456d146bcca05906e4c5d3</citedby><cites>FETCH-LOGICAL-c3529-a41c2e45c86ff98e89f62cde499327557d3f3a361f8456d146bcca05906e4c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbin.10579$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbin.10579$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26771770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Jie</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Gao, Xiaopeng</creatorcontrib><creatorcontrib>Guo, Jun</creatorcontrib><creatorcontrib>Hou, Jixue</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Wang, Sibo</creatorcontrib><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Zhang, Xuyong</creatorcontrib><creatorcontrib>Ge, Quanhu</creatorcontrib><creatorcontrib>Wan, Longfei</creatorcontrib><creatorcontrib>Cheng, Wenzhe</creatorcontrib><creatorcontrib>Zheng, Jinpo</creatorcontrib><creatorcontrib>Chen, Xueling</creatorcontrib><creatorcontrib>Wu, Xiangwei</creatorcontrib><title>E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling</title><title>Cell biology international</title><addtitle>Cell Biol Int</addtitle><description>Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are attached to each other in the bone marrow (BM) cavity and in in vitro cultures, and this adhesion has important physiological significance. We demonstrated that cell proliferation could be promoted when MSCs were co‐cultured with EPCs, which was beneficial to angiogenesis, tissue repair, and regeneration. The adhesion of MSCs and EPCs could promote the pluripotency of MSCs, particularly self‐renewal and multi‐differentiation to osteoblasts, chondrocytes, and adipocytes. This study focused on the mechanism of adhesion between EPCs and MSCs. The results showed that E‐cadherin (E‐cad) mediated the adhesion of MSCs and EPCs through the E‐cad/beta‐catenin signaling pathway. The E‐cad of EPCs occupied a dominant position during this process, which activated and up‐regulated the beta‐catenin (β‐catenin) of MSCs to improve cohesion and exert their biological function.</description><subject>adhesion</subject><subject>Animals</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>beta-catenin</subject><subject>Bone Marrow Cells - cytology</subject><subject>Cadherins - antagonists & inhibitors</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Coculture Techniques</subject><subject>E-cadherin</subject><subject>Endothelial Progenitor Cells - cytology</subject><subject>Endothelial Progenitor Cells - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microscopy, Fluorescence</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA Interference</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Signal Transduction</subject><subject>siRNA</subject><subject>transfection</subject><subject>Up-Regulation</subject><issn>1065-6995</issn><issn>1095-8355</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFOHCEUholpo9Z64wMYLhuTaWEYYLhst3bXxKhN2nhJWObMDjrDWGCj-1o-iM9Uprt62QvCSfj-n5MPoRNKPlNCyi926XyeuFR76JASxYuacf5umgUvhFL8AH2I8Y4QSqta7KODUkhJpSSHKJ0X1jQdBOeLARpnEjTYjj4Zm_DYYvDNmDronenxQxhX4F0aA7bQ9xE_utThASJ4222GTMQEw-4tdWFcrzr88pw_SDnmcXQrb3rnVx_R-9b0EY539xH6_eP812xRXF7PL2ZfLwvLeKkKU1FbQsVtLdpW1VCrVpS2gUopVkrOZcNaZpigbV1x0dBKLK01hCsioLK8YUfo07Y3b_5nDTHpwcVpPeNhXEedFfDpsDKjZ1vUhjHGAK1-CG4wYaMp0ZNlPVnW_yxn-HTXu15maW_oq9YM0C3w6HrY_KdKz75dXL2WFtuMyxaf3jIm3GshmeT69mquyeLnjVp8n-sZ-wsbw5kn</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Xia, Jie</creator><creator>Zhang, Hongwei</creator><creator>Gao, Xiaopeng</creator><creator>Guo, Jun</creator><creator>Hou, Jixue</creator><creator>Wang, Xiaoyi</creator><creator>Wang, Sibo</creator><creator>Yang, Tao</creator><creator>Zhang, Xuyong</creator><creator>Ge, Quanhu</creator><creator>Wan, Longfei</creator><creator>Cheng, Wenzhe</creator><creator>Zheng, Jinpo</creator><creator>Chen, Xueling</creator><creator>Wu, Xiangwei</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling</title><author>Xia, Jie ; Zhang, Hongwei ; Gao, Xiaopeng ; Guo, Jun ; Hou, Jixue ; Wang, Xiaoyi ; Wang, Sibo ; Yang, Tao ; Zhang, Xuyong ; Ge, Quanhu ; Wan, Longfei ; Cheng, Wenzhe ; Zheng, Jinpo ; Chen, Xueling ; Wu, Xiangwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3529-a41c2e45c86ff98e89f62cde499327557d3f3a361f8456d146bcca05906e4c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>adhesion</topic><topic>Animals</topic><topic>beta Catenin - genetics</topic><topic>beta Catenin - metabolism</topic><topic>beta-catenin</topic><topic>Bone Marrow Cells - cytology</topic><topic>Cadherins - antagonists & inhibitors</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cell Adhesion</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Coculture Techniques</topic><topic>E-cadherin</topic><topic>Endothelial Progenitor Cells - cytology</topic><topic>Endothelial Progenitor Cells - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microscopy, Fluorescence</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA Interference</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Signal Transduction</topic><topic>siRNA</topic><topic>transfection</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Jie</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Gao, Xiaopeng</creatorcontrib><creatorcontrib>Guo, Jun</creatorcontrib><creatorcontrib>Hou, Jixue</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Wang, Sibo</creatorcontrib><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Zhang, Xuyong</creatorcontrib><creatorcontrib>Ge, Quanhu</creatorcontrib><creatorcontrib>Wan, Longfei</creatorcontrib><creatorcontrib>Cheng, Wenzhe</creatorcontrib><creatorcontrib>Zheng, Jinpo</creatorcontrib><creatorcontrib>Chen, Xueling</creatorcontrib><creatorcontrib>Wu, Xiangwei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Jie</au><au>Zhang, Hongwei</au><au>Gao, Xiaopeng</au><au>Guo, Jun</au><au>Hou, Jixue</au><au>Wang, Xiaoyi</au><au>Wang, Sibo</au><au>Yang, Tao</au><au>Zhang, Xuyong</au><au>Ge, Quanhu</au><au>Wan, Longfei</au><au>Cheng, Wenzhe</au><au>Zheng, Jinpo</au><au>Chen, Xueling</au><au>Wu, Xiangwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling</atitle><jtitle>Cell biology international</jtitle><addtitle>Cell Biol Int</addtitle><date>2016-04</date><risdate>2016</risdate><volume>40</volume><issue>4</issue><spage>407</spage><epage>418</epage><pages>407-418</pages><issn>1065-6995</issn><eissn>1095-8355</eissn><abstract>Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are attached to each other in the bone marrow (BM) cavity and in in vitro cultures, and this adhesion has important physiological significance. We demonstrated that cell proliferation could be promoted when MSCs were co‐cultured with EPCs, which was beneficial to angiogenesis, tissue repair, and regeneration. The adhesion of MSCs and EPCs could promote the pluripotency of MSCs, particularly self‐renewal and multi‐differentiation to osteoblasts, chondrocytes, and adipocytes. This study focused on the mechanism of adhesion between EPCs and MSCs. The results showed that E‐cadherin (E‐cad) mediated the adhesion of MSCs and EPCs through the E‐cad/beta‐catenin signaling pathway. The E‐cad of EPCs occupied a dominant position during this process, which activated and up‐regulated the beta‐catenin (β‐catenin) of MSCs to improve cohesion and exert their biological function.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26771770</pmid><doi>10.1002/cbin.10579</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1065-6995 |
| ispartof | Cell biology international, 2016-04, Vol.40 (4), p.407-418 |
| issn | 1065-6995 1095-8355 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1775177532 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | adhesion Animals beta Catenin - genetics beta Catenin - metabolism beta-catenin Bone Marrow Cells - cytology Cadherins - antagonists & inhibitors Cadherins - genetics Cadherins - metabolism Cell Adhesion Cell Differentiation Cells, Cultured Coculture Techniques E-cadherin Endothelial Progenitor Cells - cytology Endothelial Progenitor Cells - metabolism Enzyme-Linked Immunosorbent Assay Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Microscopy, Fluorescence Real-Time Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Signal Transduction siRNA transfection Up-Regulation |
| title | E-cadherin-mediated contact of endothelial progenitor cells with mesenchymal stem cells through β-catenin signaling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T20%3A49%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=E-cadherin-mediated%20contact%20of%20endothelial%20progenitor%20cells%20with%20mesenchymal%20stem%20cells%20through%20%CE%B2-catenin%20signaling&rft.jtitle=Cell%20biology%20international&rft.au=Xia,%20Jie&rft.date=2016-04&rft.volume=40&rft.issue=4&rft.spage=407&rft.epage=418&rft.pages=407-418&rft.issn=1065-6995&rft.eissn=1095-8355&rft_id=info:doi/10.1002/cbin.10579&rft_dat=%3Cproquest_cross%3E1775177532%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1775177532&rft_id=info:pmid/26771770&rfr_iscdi=true |