Neutral Endopeptidase Terminates Substance P-Induced Inflammation in Allergic Contact Dermatitis

Sensory nerve-derived neuropeptides such as substance P demonstrate a number of proinflammatory bioactivities, but less is known about their role in inflammatory skin disease. The cell surface metalloprotease neutral endopeptidase (NEP) is the principal proteolytic substance P-degrading enzyme. This...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (2), p.1285-1291
Hauptverfasser:	Scholzen, Thomas E, Steinhoff, Martin, Bonaccorsi, Paola, Klein, Robin, Amadesi, Silvia, Geppetti, Piero, Lu, Bao, Gerard, Norma P, Olerud, John E, Luger, Thomas A, Bunnett, Nigel W, Grady, Eileen F, Armstrong, Cheryl A, Ansel, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Capillary Permeability - genetics Capillary Permeability - immunology Capsaicin - administration & dosage Croton Oil - toxicity Dermatitis, Allergic Contact - enzymology Dermatitis, Allergic Contact - genetics Dermatitis, Allergic Contact - pathology Dermatitis, Allergic Contact - prevention & control Dermatitis, Irritant - enzymology Dermatitis, Irritant - genetics Dermatitis, Irritant - pathology Dermatitis, Irritant - prevention & control Enzyme Inhibitors - administration & dosage Female Glycopeptides - administration & dosage Injections, Intravenous Male Mice Mice, Inbred C57BL Mice, Knockout Neprilysin - antagonists & inhibitors Neprilysin - deficiency Neprilysin - metabolism Neprilysin - physiology Neurokinin-1 Receptor Antagonists Piperidines - administration & dosage Quinuclidines - administration & dosage Skin - blood supply Skin - enzymology Skin - pathology Substance P - toxicity
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