Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis
Summary Allogeneic hematopoietic stem cell transplantation (HSCT)-related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood...
Gespeichert in:
| Veröffentlicht in: | Human pathology 2016-04, Vol.50, p.187-194 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 194 |
|---|---|
| container_issue | |
| container_start_page | 187 |
| container_title | Human pathology |
| container_volume | 50 |
| creator | Hiramatsu, Rikako, MD Ubara, Yoshifumi, MD, PhD Sawa, Naoki, MD Hasegawa, Eiko, MD Kawada, Masahiro, MD Imafuku, Aya, MD Sumida, Keiichi, MD Mise, Koki, MD Yamanouchi, Masayuki, MD Ueno, Toshiharu, MD Sekine, Akinari, MD Hayami, Noriko, MD Suwabe, Tatsuya, MD Hoshino, Junichi, MD Takaichi, Kenmei, MD Ohashi, Kenichi, MD Fujii, Takeshi Wake, Atsushi Taniguchi, Shuichi |
| description | Summary Allogeneic hematopoietic stem cell transplantation (HSCT)-related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood transplantation (UCBT) and 208 patients receiving unrelated bone marrow transplantation (BMT). MGN was diagnosed in 5 patients after UCBT (vs. none after BMT), and occurred concomitantly with chronic graft-versus-host-disease after cessation of immunosuppression. LM did not show any definite spikes or bubbling of the glomerular basement membrane (GBM) in all 5 patients. In 1 patient (case 5), endocapillary proliferative lesions with fibrin-like deposits were noted in addition to MGN findings. IF demonstrated granular deposits of IgG (IgG1 and IgG4) along the GBM with negativity for C3, C4, and C1q in 4 patients (cases 1-4), while case 5 showed positivity for IgG (IgG1, IgG2, IgG3, and IgG4) as well as for C3, C4, and C1q. EM revealed electron-dense deposits (EDD) in the subepithelial space of the GBM in cases 1-4. In case 5, EDD were present in the mesangium and the subendothelial space of the GBM, as well as in the subepithelial space. After treatment with immunosuppressants (prednisolone and/or cyclosporin) or angiotensin-converting enzyme inhibitors, complete remission with disappearance of proteinuria was achieved 12.2 months in all 5 patients, but nephrotic range proteinuria relapsed in two patients during follow up. Serum anti-PLA2R autoantibody was negative in three patients. HSCT-related MGN only occurred after umbilical cord blood transplantation (UCBT). We believe that there were two morphologic patterns; early MGN and membranoproliferative pattern glomerulonephritis. |
| doi_str_mv | 10.1016/j.humpath.2015.12.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1775170778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0046817715004967</els_id><sourcerecordid>4319290321</sourcerecordid><originalsourceid>FETCH-LOGICAL-c561t-a47ed16c957b66a4bf03ff94e59231be0783d178de82977fb7e0973e6527b2af3</originalsourceid><addsrcrecordid>eNqFUk1v1DAUtBCILlt-AigSFy4JthPbyQW0WvUDqaiHlrPlOC-sFycOtoO6_75OdwGpF07-mpn3PPMQekdwQTDhn_bFbh4mFXcFxYQVhBYYsxdoRVhJ87ps6Eu0wrjieU2EOENvQthjTAir2Gt0RnnTiIqxFXrYWjMa7RYlZ90Po5XNNqOyh2BC5vpsY9MtjGB0dg2Dim5yBmI63UUYsi1Ym917NYbJqjGqaNyYe7AqQpd9g6FNT24O2ZV1A_jZuhGmnTfRhHP0qlc2wNvTukbfLy_ut9f5ze3V1-3mJteMk5irSkBHuG6YaDlXVdvjsu-bClhDS9ICFnXZEVF3UNNGiL4VgBtRAmdUtFT15Rp9POpO3v2aIUQ5mKBT22qE1JlM7jAisEg6a_ThGXTvZp-8SKhaVHVFKGYJxY4o7V0IHno5eTMof5AEyyUauZenaOQSjSRU4ife-5P63A7Q_WX9ySIBvhwBkOz4bcDLoA2MGjrjQUfZOfPfEp-fKeindJX9CQcI_34jQyLIu2U-lvEgLO0aLspHWzG5dQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874841205</pqid></control><display><type>article</type><title>Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hiramatsu, Rikako, MD ; Ubara, Yoshifumi, MD, PhD ; Sawa, Naoki, MD ; Hasegawa, Eiko, MD ; Kawada, Masahiro, MD ; Imafuku, Aya, MD ; Sumida, Keiichi, MD ; Mise, Koki, MD ; Yamanouchi, Masayuki, MD ; Ueno, Toshiharu, MD ; Sekine, Akinari, MD ; Hayami, Noriko, MD ; Suwabe, Tatsuya, MD ; Hoshino, Junichi, MD ; Takaichi, Kenmei, MD ; Ohashi, Kenichi, MD ; Fujii, Takeshi ; Wake, Atsushi ; Taniguchi, Shuichi</creator><creatorcontrib>Hiramatsu, Rikako, MD ; Ubara, Yoshifumi, MD, PhD ; Sawa, Naoki, MD ; Hasegawa, Eiko, MD ; Kawada, Masahiro, MD ; Imafuku, Aya, MD ; Sumida, Keiichi, MD ; Mise, Koki, MD ; Yamanouchi, Masayuki, MD ; Ueno, Toshiharu, MD ; Sekine, Akinari, MD ; Hayami, Noriko, MD ; Suwabe, Tatsuya, MD ; Hoshino, Junichi, MD ; Takaichi, Kenmei, MD ; Ohashi, Kenichi, MD ; Fujii, Takeshi ; Wake, Atsushi ; Taniguchi, Shuichi</creatorcontrib><description>Summary Allogeneic hematopoietic stem cell transplantation (HSCT)-related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood transplantation (UCBT) and 208 patients receiving unrelated bone marrow transplantation (BMT). MGN was diagnosed in 5 patients after UCBT (vs. none after BMT), and occurred concomitantly with chronic graft-versus-host-disease after cessation of immunosuppression. LM did not show any definite spikes or bubbling of the glomerular basement membrane (GBM) in all 5 patients. In 1 patient (case 5), endocapillary proliferative lesions with fibrin-like deposits were noted in addition to MGN findings. IF demonstrated granular deposits of IgG (IgG1 and IgG4) along the GBM with negativity for C3, C4, and C1q in 4 patients (cases 1-4), while case 5 showed positivity for IgG (IgG1, IgG2, IgG3, and IgG4) as well as for C3, C4, and C1q. EM revealed electron-dense deposits (EDD) in the subepithelial space of the GBM in cases 1-4. In case 5, EDD were present in the mesangium and the subendothelial space of the GBM, as well as in the subepithelial space. After treatment with immunosuppressants (prednisolone and/or cyclosporin) or angiotensin-converting enzyme inhibitors, complete remission with disappearance of proteinuria was achieved 12.2 months in all 5 patients, but nephrotic range proteinuria relapsed in two patients during follow up. Serum anti-PLA2R autoantibody was negative in three patients. HSCT-related MGN only occurred after umbilical cord blood transplantation (UCBT). We believe that there were two morphologic patterns; early MGN and membranoproliferative pattern glomerulonephritis.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2015.12.005</identifier><identifier>PMID: 26997455</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Allogeneic hematopoietic cell transplantation ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Anti-PLA2R autoantibody ; Biomarkers - analysis ; Biopsy ; Blood ; Chronic graft-versus-host disease ; Disease ; Enzymes ; Female ; Fluorescent Antibody Technique ; Gangrene ; Glomerulonephritis, Membranoproliferative - diagnosis ; Glomerulonephritis, Membranoproliferative - drug therapy ; Glomerulonephritis, Membranoproliferative - etiology ; Glomerulonephritis, Membranous - diagnosis ; Glomerulonephritis, Membranous - drug therapy ; Glomerulonephritis, Membranous - etiology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hepatitis ; Histology ; Humans ; Immunosuppressive Agents - therapeutic use ; Japan ; Kidney - chemistry ; Kidney - drug effects ; Kidney - immunology ; Kidney - ultrastructure ; Laboratories ; Leukemia ; Lymphoma ; Male ; Membranoproliferative pattern glomerulonephritis ; Membranous glomerulonephritis ; Microscopy ; Microscopy, Electron ; Middle Aged ; Pathology ; Patients ; Proteins ; Proteinuria - etiology ; Remission Induction ; Retrospective Studies ; Statistical analysis ; Stem cells ; Time Factors ; Transplantation, Homologous ; Treatment Outcome ; Umbilical cord blood transplantation ; Unrelated bone marrow transplantation ; Urine</subject><ispartof>Human pathology, 2016-04, Vol.50, p.187-194</ispartof><rights>2015 The Authors</rights><rights>Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 01, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-a47ed16c957b66a4bf03ff94e59231be0783d178de82977fb7e0973e6527b2af3</citedby><cites>FETCH-LOGICAL-c561t-a47ed16c957b66a4bf03ff94e59231be0783d178de82977fb7e0973e6527b2af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817715004967$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26997455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiramatsu, Rikako, MD</creatorcontrib><creatorcontrib>Ubara, Yoshifumi, MD, PhD</creatorcontrib><creatorcontrib>Sawa, Naoki, MD</creatorcontrib><creatorcontrib>Hasegawa, Eiko, MD</creatorcontrib><creatorcontrib>Kawada, Masahiro, MD</creatorcontrib><creatorcontrib>Imafuku, Aya, MD</creatorcontrib><creatorcontrib>Sumida, Keiichi, MD</creatorcontrib><creatorcontrib>Mise, Koki, MD</creatorcontrib><creatorcontrib>Yamanouchi, Masayuki, MD</creatorcontrib><creatorcontrib>Ueno, Toshiharu, MD</creatorcontrib><creatorcontrib>Sekine, Akinari, MD</creatorcontrib><creatorcontrib>Hayami, Noriko, MD</creatorcontrib><creatorcontrib>Suwabe, Tatsuya, MD</creatorcontrib><creatorcontrib>Hoshino, Junichi, MD</creatorcontrib><creatorcontrib>Takaichi, Kenmei, MD</creatorcontrib><creatorcontrib>Ohashi, Kenichi, MD</creatorcontrib><creatorcontrib>Fujii, Takeshi</creatorcontrib><creatorcontrib>Wake, Atsushi</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><title>Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Allogeneic hematopoietic stem cell transplantation (HSCT)-related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood transplantation (UCBT) and 208 patients receiving unrelated bone marrow transplantation (BMT). MGN was diagnosed in 5 patients after UCBT (vs. none after BMT), and occurred concomitantly with chronic graft-versus-host-disease after cessation of immunosuppression. LM did not show any definite spikes or bubbling of the glomerular basement membrane (GBM) in all 5 patients. In 1 patient (case 5), endocapillary proliferative lesions with fibrin-like deposits were noted in addition to MGN findings. IF demonstrated granular deposits of IgG (IgG1 and IgG4) along the GBM with negativity for C3, C4, and C1q in 4 patients (cases 1-4), while case 5 showed positivity for IgG (IgG1, IgG2, IgG3, and IgG4) as well as for C3, C4, and C1q. EM revealed electron-dense deposits (EDD) in the subepithelial space of the GBM in cases 1-4. In case 5, EDD were present in the mesangium and the subendothelial space of the GBM, as well as in the subepithelial space. After treatment with immunosuppressants (prednisolone and/or cyclosporin) or angiotensin-converting enzyme inhibitors, complete remission with disappearance of proteinuria was achieved 12.2 months in all 5 patients, but nephrotic range proteinuria relapsed in two patients during follow up. Serum anti-PLA2R autoantibody was negative in three patients. HSCT-related MGN only occurred after umbilical cord blood transplantation (UCBT). We believe that there were two morphologic patterns; early MGN and membranoproliferative pattern glomerulonephritis.</description><subject>Adult</subject><subject>Allogeneic hematopoietic cell transplantation</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Anti-PLA2R autoantibody</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Chronic graft-versus-host disease</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Gangrene</subject><subject>Glomerulonephritis, Membranoproliferative - diagnosis</subject><subject>Glomerulonephritis, Membranoproliferative - drug therapy</subject><subject>Glomerulonephritis, Membranoproliferative - etiology</subject><subject>Glomerulonephritis, Membranous - diagnosis</subject><subject>Glomerulonephritis, Membranous - drug therapy</subject><subject>Glomerulonephritis, Membranous - etiology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hepatitis</subject><subject>Histology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Japan</subject><subject>Kidney - chemistry</subject><subject>Kidney - drug effects</subject><subject>Kidney - immunology</subject><subject>Kidney - ultrastructure</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Membranoproliferative pattern glomerulonephritis</subject><subject>Membranous glomerulonephritis</subject><subject>Microscopy</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Patients</subject><subject>Proteins</subject><subject>Proteinuria - etiology</subject><subject>Remission Induction</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Stem cells</subject><subject>Time Factors</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><subject>Umbilical cord blood transplantation</subject><subject>Unrelated bone marrow transplantation</subject><subject>Urine</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAUtBCILlt-AigSFy4JthPbyQW0WvUDqaiHlrPlOC-sFycOtoO6_75OdwGpF07-mpn3PPMQekdwQTDhn_bFbh4mFXcFxYQVhBYYsxdoRVhJ87ps6Eu0wrjieU2EOENvQthjTAir2Gt0RnnTiIqxFXrYWjMa7RYlZ90Po5XNNqOyh2BC5vpsY9MtjGB0dg2Dim5yBmI63UUYsi1Ym917NYbJqjGqaNyYe7AqQpd9g6FNT24O2ZV1A_jZuhGmnTfRhHP0qlc2wNvTukbfLy_ut9f5ze3V1-3mJteMk5irSkBHuG6YaDlXVdvjsu-bClhDS9ICFnXZEVF3UNNGiL4VgBtRAmdUtFT15Rp9POpO3v2aIUQ5mKBT22qE1JlM7jAisEg6a_ThGXTvZp-8SKhaVHVFKGYJxY4o7V0IHno5eTMof5AEyyUauZenaOQSjSRU4ife-5P63A7Q_WX9ySIBvhwBkOz4bcDLoA2MGjrjQUfZOfPfEp-fKeindJX9CQcI_34jQyLIu2U-lvEgLO0aLspHWzG5dQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Hiramatsu, Rikako, MD</creator><creator>Ubara, Yoshifumi, MD, PhD</creator><creator>Sawa, Naoki, MD</creator><creator>Hasegawa, Eiko, MD</creator><creator>Kawada, Masahiro, MD</creator><creator>Imafuku, Aya, MD</creator><creator>Sumida, Keiichi, MD</creator><creator>Mise, Koki, MD</creator><creator>Yamanouchi, Masayuki, MD</creator><creator>Ueno, Toshiharu, MD</creator><creator>Sekine, Akinari, MD</creator><creator>Hayami, Noriko, MD</creator><creator>Suwabe, Tatsuya, MD</creator><creator>Hoshino, Junichi, MD</creator><creator>Takaichi, Kenmei, MD</creator><creator>Ohashi, Kenichi, MD</creator><creator>Fujii, Takeshi</creator><creator>Wake, Atsushi</creator><creator>Taniguchi, Shuichi</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis</title><author>Hiramatsu, Rikako, MD ; Ubara, Yoshifumi, MD, PhD ; Sawa, Naoki, MD ; Hasegawa, Eiko, MD ; Kawada, Masahiro, MD ; Imafuku, Aya, MD ; Sumida, Keiichi, MD ; Mise, Koki, MD ; Yamanouchi, Masayuki, MD ; Ueno, Toshiharu, MD ; Sekine, Akinari, MD ; Hayami, Noriko, MD ; Suwabe, Tatsuya, MD ; Hoshino, Junichi, MD ; Takaichi, Kenmei, MD ; Ohashi, Kenichi, MD ; Fujii, Takeshi ; Wake, Atsushi ; Taniguchi, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-a47ed16c957b66a4bf03ff94e59231be0783d178de82977fb7e0973e6527b2af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Allogeneic hematopoietic cell transplantation</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Anti-PLA2R autoantibody</topic><topic>Biomarkers - analysis</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Chronic graft-versus-host disease</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Gangrene</topic><topic>Glomerulonephritis, Membranoproliferative - diagnosis</topic><topic>Glomerulonephritis, Membranoproliferative - drug therapy</topic><topic>Glomerulonephritis, Membranoproliferative - etiology</topic><topic>Glomerulonephritis, Membranous - diagnosis</topic><topic>Glomerulonephritis, Membranous - drug therapy</topic><topic>Glomerulonephritis, Membranous - etiology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hepatitis</topic><topic>Histology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Japan</topic><topic>Kidney - chemistry</topic><topic>Kidney - drug effects</topic><topic>Kidney - immunology</topic><topic>Kidney - ultrastructure</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Membranoproliferative pattern glomerulonephritis</topic><topic>Membranous glomerulonephritis</topic><topic>Microscopy</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Patients</topic><topic>Proteins</topic><topic>Proteinuria - etiology</topic><topic>Remission Induction</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Stem cells</topic><topic>Time Factors</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><topic>Umbilical cord blood transplantation</topic><topic>Unrelated bone marrow transplantation</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiramatsu, Rikako, MD</creatorcontrib><creatorcontrib>Ubara, Yoshifumi, MD, PhD</creatorcontrib><creatorcontrib>Sawa, Naoki, MD</creatorcontrib><creatorcontrib>Hasegawa, Eiko, MD</creatorcontrib><creatorcontrib>Kawada, Masahiro, MD</creatorcontrib><creatorcontrib>Imafuku, Aya, MD</creatorcontrib><creatorcontrib>Sumida, Keiichi, MD</creatorcontrib><creatorcontrib>Mise, Koki, MD</creatorcontrib><creatorcontrib>Yamanouchi, Masayuki, MD</creatorcontrib><creatorcontrib>Ueno, Toshiharu, MD</creatorcontrib><creatorcontrib>Sekine, Akinari, MD</creatorcontrib><creatorcontrib>Hayami, Noriko, MD</creatorcontrib><creatorcontrib>Suwabe, Tatsuya, MD</creatorcontrib><creatorcontrib>Hoshino, Junichi, MD</creatorcontrib><creatorcontrib>Takaichi, Kenmei, MD</creatorcontrib><creatorcontrib>Ohashi, Kenichi, MD</creatorcontrib><creatorcontrib>Fujii, Takeshi</creatorcontrib><creatorcontrib>Wake, Atsushi</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiramatsu, Rikako, MD</au><au>Ubara, Yoshifumi, MD, PhD</au><au>Sawa, Naoki, MD</au><au>Hasegawa, Eiko, MD</au><au>Kawada, Masahiro, MD</au><au>Imafuku, Aya, MD</au><au>Sumida, Keiichi, MD</au><au>Mise, Koki, MD</au><au>Yamanouchi, Masayuki, MD</au><au>Ueno, Toshiharu, MD</au><au>Sekine, Akinari, MD</au><au>Hayami, Noriko, MD</au><au>Suwabe, Tatsuya, MD</au><au>Hoshino, Junichi, MD</au><au>Takaichi, Kenmei, MD</au><au>Ohashi, Kenichi, MD</au><au>Fujii, Takeshi</au><au>Wake, Atsushi</au><au>Taniguchi, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>50</volume><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Summary Allogeneic hematopoietic stem cell transplantation (HSCT)-related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood transplantation (UCBT) and 208 patients receiving unrelated bone marrow transplantation (BMT). MGN was diagnosed in 5 patients after UCBT (vs. none after BMT), and occurred concomitantly with chronic graft-versus-host-disease after cessation of immunosuppression. LM did not show any definite spikes or bubbling of the glomerular basement membrane (GBM) in all 5 patients. In 1 patient (case 5), endocapillary proliferative lesions with fibrin-like deposits were noted in addition to MGN findings. IF demonstrated granular deposits of IgG (IgG1 and IgG4) along the GBM with negativity for C3, C4, and C1q in 4 patients (cases 1-4), while case 5 showed positivity for IgG (IgG1, IgG2, IgG3, and IgG4) as well as for C3, C4, and C1q. EM revealed electron-dense deposits (EDD) in the subepithelial space of the GBM in cases 1-4. In case 5, EDD were present in the mesangium and the subendothelial space of the GBM, as well as in the subepithelial space. After treatment with immunosuppressants (prednisolone and/or cyclosporin) or angiotensin-converting enzyme inhibitors, complete remission with disappearance of proteinuria was achieved 12.2 months in all 5 patients, but nephrotic range proteinuria relapsed in two patients during follow up. Serum anti-PLA2R autoantibody was negative in three patients. HSCT-related MGN only occurred after umbilical cord blood transplantation (UCBT). We believe that there were two morphologic patterns; early MGN and membranoproliferative pattern glomerulonephritis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26997455</pmid><doi>10.1016/j.humpath.2015.12.005</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 2016-04, Vol.50, p.187-194 |
| issn | 0046-8177 1532-8392 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1775170778 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Allogeneic hematopoietic cell transplantation Angiotensin-Converting Enzyme Inhibitors - therapeutic use Anti-PLA2R autoantibody Biomarkers - analysis Biopsy Blood Chronic graft-versus-host disease Disease Enzymes Female Fluorescent Antibody Technique Gangrene Glomerulonephritis, Membranoproliferative - diagnosis Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - etiology Glomerulonephritis, Membranous - diagnosis Glomerulonephritis, Membranous - drug therapy Glomerulonephritis, Membranous - etiology Hematopoietic Stem Cell Transplantation - adverse effects Hepatitis Histology Humans Immunosuppressive Agents - therapeutic use Japan Kidney - chemistry Kidney - drug effects Kidney - immunology Kidney - ultrastructure Laboratories Leukemia Lymphoma Male Membranoproliferative pattern glomerulonephritis Membranous glomerulonephritis Microscopy Microscopy, Electron Middle Aged Pathology Patients Proteins Proteinuria - etiology Remission Induction Retrospective Studies Statistical analysis Stem cells Time Factors Transplantation, Homologous Treatment Outcome Umbilical cord blood transplantation Unrelated bone marrow transplantation Urine |
| title | Clinicopathological Analysis of Allogeneic Hematopoietic Stem Cell Transplantation-related Membranous Glomerulonephritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A15%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathological%20Analysis%20of%20Allogeneic%20Hematopoietic%20Stem%20Cell%20Transplantation-related%20Membranous%20Glomerulonephritis&rft.jtitle=Human%20pathology&rft.au=Hiramatsu,%20Rikako,%20MD&rft.date=2016-04-01&rft.volume=50&rft.spage=187&rft.epage=194&rft.pages=187-194&rft.issn=0046-8177&rft.eissn=1532-8392&rft_id=info:doi/10.1016/j.humpath.2015.12.005&rft_dat=%3Cproquest_cross%3E4319290321%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1874841205&rft_id=info:pmid/26997455&rft_els_id=S0046817715004967&rfr_iscdi=true |