Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI
We aimed to evaluate the effects and the interaction of size of the preovulatory follicle (POF) and long-acting progesterone (P4) supplementation after timed-AI on CL function and pregnancy success in beef cows. In experiment 1, ovulations of beef cows were synchronized starting on Day −10, and cows...
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| Veröffentlicht in: | Theriogenology 2016-04, Vol.85 (7), p.1239-1248 |
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| creator | Pugliesi, G. Santos, F.B. Lopes, E. Nogueira, É. Maio, J.R.G. Binelli, M. |
| description | We aimed to evaluate the effects and the interaction of size of the preovulatory follicle (POF) and long-acting progesterone (P4) supplementation after timed-AI on CL function and pregnancy success in beef cows. In experiment 1, ovulations of beef cows were synchronized starting on Day −10, and cows were split to receive sodium cloprostenol (large follicle group; LF; n = 31) or nothing (small follicle group; SF; n = 35). Ovulations were induced on Day 0, and cows were inseminated. Ovulated cows were assigned to receive placebo (LF/control group, n = 14; and SF/control group, n = 9) or 150 mg of long-acting P4 on Day 4.5 (LF/P4 group, n = 13; and SF/P4 group, n = 12). Diameter of POF, blood flow in POF wall, ovulation rate, and size and vascularization of CL were greater (P 0.1) between P4-treated (53.2%; 209/393) and control cows (56.2%; 219/390), but P/AI was greater in cows with a CL |
| doi_str_mv | 10.1016/j.theriogenology.2015.12.006 |
| format | Article |
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In experiment 1, ovulations of beef cows were synchronized starting on Day −10, and cows were split to receive sodium cloprostenol (large follicle group; LF; n = 31) or nothing (small follicle group; SF; n = 35). Ovulations were induced on Day 0, and cows were inseminated. Ovulated cows were assigned to receive placebo (LF/control group, n = 14; and SF/control group, n = 9) or 150 mg of long-acting P4 on Day 4.5 (LF/P4 group, n = 13; and SF/P4 group, n = 12). Diameter of POF, blood flow in POF wall, ovulation rate, and size and vascularization of CL were greater (P < 0.05) in LF group. In experiments 2 (unknown cyclic status) and 4 (noncycling), ovulations were synchronized, and beef cows received placebo or 150 mg of long-acting P4 on Day 4 after timed-artificial insemination. In experiment 2, pregnancy/AI (P/AI) did not differ (P > 0.1) between P4-treated (53.2%; 209/393) and control cows (56.2%; 219/390), but P/AI was greater in cows with a CL < 0.9 cm2 on Day 4 that were P4-treated (57.9%, 22/38) versus placebo-treated (40.4%, 21/52; P < 0.05). In Experiment 4, P/AI was greater (P < 0.05) in P4-treated cows (55.6%, 105/189 vs. 46.0%, 86/187). In Experiment 3, cyclic–suckled beef cows were treated as described in Experiment 1 to generate animals with small (SF; n = 111) or large POF (LF; n = 109), and subdivided to receive placebo or P4 on Day 4. POF size, ovulation rate, CL area, and P/AI were greater (P < 0.007) in the LF group. Pregnancy/AI in ovulated cows were lower (P = 0.05) in the SF/control group (41.5%, 17/41) compared to LF/control group (62%, 31/50) and were similar for the SF/P4 group (55.6%, 25/45) and LF/P4 group (57%, 28/49) compared to others. In summary, smaller and less vascularized POF results in less functional CL and reduces ovulatory rate and P/AI in cyclic beef cows; the long-acting P4 injection on Day 4 after timed-artificial insemination may attenuate the negative effects of small POF/CL; and postovulatory P4 supplementation improved fertility in anestrous beef cattle.</description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/j.theriogenology.2015.12.006</identifier><identifier>PMID: 26764150</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anestrous ; Animals ; Animals, Suckling ; Cattle ; Cell Size ; Embryo ; Estrous cycle ; Estrous Cycle - physiology ; Estrus Synchronization - methods ; Female ; Fertility - drug effects ; Fertility Agents, Female - administration & dosage ; Insemination, Artificial - veterinary ; Lactation - physiology ; Ovarian Follicle - physiology ; Ovulation - physiology ; Pregnancy ; Progesterone - administration & dosage ; Progesterone - pharmacology ; Uterus</subject><ispartof>Theriogenology, 2016-04, Vol.85 (7), p.1239-1248</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-5fe2292899301ccffc9e1cd4e7664713f17cbe7d0c8e7ae0b7d09514001b181b3</citedby><cites>FETCH-LOGICAL-c456t-5fe2292899301ccffc9e1cd4e7664713f17cbe7d0c8e7ae0b7d09514001b181b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093691X15006792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26764150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pugliesi, G.</creatorcontrib><creatorcontrib>Santos, F.B.</creatorcontrib><creatorcontrib>Lopes, E.</creatorcontrib><creatorcontrib>Nogueira, É.</creatorcontrib><creatorcontrib>Maio, J.R.G.</creatorcontrib><creatorcontrib>Binelli, M.</creatorcontrib><title>Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description>We aimed to evaluate the effects and the interaction of size of the preovulatory follicle (POF) and long-acting progesterone (P4) supplementation after timed-AI on CL function and pregnancy success in beef cows. In experiment 1, ovulations of beef cows were synchronized starting on Day −10, and cows were split to receive sodium cloprostenol (large follicle group; LF; n = 31) or nothing (small follicle group; SF; n = 35). Ovulations were induced on Day 0, and cows were inseminated. Ovulated cows were assigned to receive placebo (LF/control group, n = 14; and SF/control group, n = 9) or 150 mg of long-acting P4 on Day 4.5 (LF/P4 group, n = 13; and SF/P4 group, n = 12). Diameter of POF, blood flow in POF wall, ovulation rate, and size and vascularization of CL were greater (P < 0.05) in LF group. In experiments 2 (unknown cyclic status) and 4 (noncycling), ovulations were synchronized, and beef cows received placebo or 150 mg of long-acting P4 on Day 4 after timed-artificial insemination. In experiment 2, pregnancy/AI (P/AI) did not differ (P > 0.1) between P4-treated (53.2%; 209/393) and control cows (56.2%; 219/390), but P/AI was greater in cows with a CL < 0.9 cm2 on Day 4 that were P4-treated (57.9%, 22/38) versus placebo-treated (40.4%, 21/52; P < 0.05). In Experiment 4, P/AI was greater (P < 0.05) in P4-treated cows (55.6%, 105/189 vs. 46.0%, 86/187). In Experiment 3, cyclic–suckled beef cows were treated as described in Experiment 1 to generate animals with small (SF; n = 111) or large POF (LF; n = 109), and subdivided to receive placebo or P4 on Day 4. POF size, ovulation rate, CL area, and P/AI were greater (P < 0.007) in the LF group. Pregnancy/AI in ovulated cows were lower (P = 0.05) in the SF/control group (41.5%, 17/41) compared to LF/control group (62%, 31/50) and were similar for the SF/P4 group (55.6%, 25/45) and LF/P4 group (57%, 28/49) compared to others. In summary, smaller and less vascularized POF results in less functional CL and reduces ovulatory rate and P/AI in cyclic beef cows; the long-acting P4 injection on Day 4 after timed-artificial insemination may attenuate the negative effects of small POF/CL; and postovulatory P4 supplementation improved fertility in anestrous beef cattle.</description><subject>Anestrous</subject><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Cattle</subject><subject>Cell Size</subject><subject>Embryo</subject><subject>Estrous cycle</subject><subject>Estrous Cycle - physiology</subject><subject>Estrus Synchronization - methods</subject><subject>Female</subject><subject>Fertility - drug effects</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Insemination, Artificial - veterinary</subject><subject>Lactation - physiology</subject><subject>Ovarian Follicle - physiology</subject><subject>Ovulation - physiology</subject><subject>Pregnancy</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - pharmacology</subject><subject>Uterus</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v3CAQxVHUqNmm_QoRhx56scP4DyxSL1HUtCtFyiWRekM2Hhy22GwBb7SXfvaSbhqpt54YMb_Hm-ER8hFYCQz45bZMjxisH3H2zo-HsmLQllCVjPETsoK1kEVd1fCGrBiTdcElfD8j72LcMsZqzuEtOau44A20bEV-baZd8HscqMGQrLPpQO1M46J_uHzZIxqq_VOkfr-4Ltl5pK4LI1LjnbPaYe6EjO92DiecU9Y82fRInZ_HotN_BNlgxJgw-BlpZ3JBk51wKK4278mp6VzEDy_nOXm4-XJ__a24vfu6ub66LXTT8lS0BqtKVmspawZaG6Mlgh4aFJw3AmoDQvcoBqbXKDpkfS5lCw1j0MMa-vqcfDq-m2f5ueRh1GSjRue6Gf0SFQjRAheSy4x-PqI6-BgDGrULdurCQQFTzwmorfo3AfWcgIJK5QSy_OLFaenzjq_iv1-egZsjgHnfvcWgorY4axxsQJ3U4O3_Of0G7fejpw</recordid><startdate>20160415</startdate><enddate>20160415</enddate><creator>Pugliesi, G.</creator><creator>Santos, F.B.</creator><creator>Lopes, E.</creator><creator>Nogueira, É.</creator><creator>Maio, J.R.G.</creator><creator>Binelli, M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160415</creationdate><title>Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI</title><author>Pugliesi, G. ; Santos, F.B. ; Lopes, E. ; Nogueira, É. ; Maio, J.R.G. ; Binelli, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-5fe2292899301ccffc9e1cd4e7664713f17cbe7d0c8e7ae0b7d09514001b181b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anestrous</topic><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Cattle</topic><topic>Cell Size</topic><topic>Embryo</topic><topic>Estrous cycle</topic><topic>Estrous Cycle - physiology</topic><topic>Estrus Synchronization - methods</topic><topic>Female</topic><topic>Fertility - drug effects</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Insemination, Artificial - veterinary</topic><topic>Lactation - physiology</topic><topic>Ovarian Follicle - physiology</topic><topic>Ovulation - physiology</topic><topic>Pregnancy</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - pharmacology</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pugliesi, G.</creatorcontrib><creatorcontrib>Santos, F.B.</creatorcontrib><creatorcontrib>Lopes, E.</creatorcontrib><creatorcontrib>Nogueira, É.</creatorcontrib><creatorcontrib>Maio, J.R.G.</creatorcontrib><creatorcontrib>Binelli, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pugliesi, G.</au><au>Santos, F.B.</au><au>Lopes, E.</au><au>Nogueira, É.</au><au>Maio, J.R.G.</au><au>Binelli, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2016-04-15</date><risdate>2016</risdate><volume>85</volume><issue>7</issue><spage>1239</spage><epage>1248</epage><pages>1239-1248</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract>We aimed to evaluate the effects and the interaction of size of the preovulatory follicle (POF) and long-acting progesterone (P4) supplementation after timed-AI on CL function and pregnancy success in beef cows. In experiment 1, ovulations of beef cows were synchronized starting on Day −10, and cows were split to receive sodium cloprostenol (large follicle group; LF; n = 31) or nothing (small follicle group; SF; n = 35). Ovulations were induced on Day 0, and cows were inseminated. Ovulated cows were assigned to receive placebo (LF/control group, n = 14; and SF/control group, n = 9) or 150 mg of long-acting P4 on Day 4.5 (LF/P4 group, n = 13; and SF/P4 group, n = 12). Diameter of POF, blood flow in POF wall, ovulation rate, and size and vascularization of CL were greater (P < 0.05) in LF group. In experiments 2 (unknown cyclic status) and 4 (noncycling), ovulations were synchronized, and beef cows received placebo or 150 mg of long-acting P4 on Day 4 after timed-artificial insemination. In experiment 2, pregnancy/AI (P/AI) did not differ (P > 0.1) between P4-treated (53.2%; 209/393) and control cows (56.2%; 219/390), but P/AI was greater in cows with a CL < 0.9 cm2 on Day 4 that were P4-treated (57.9%, 22/38) versus placebo-treated (40.4%, 21/52; P < 0.05). In Experiment 4, P/AI was greater (P < 0.05) in P4-treated cows (55.6%, 105/189 vs. 46.0%, 86/187). In Experiment 3, cyclic–suckled beef cows were treated as described in Experiment 1 to generate animals with small (SF; n = 111) or large POF (LF; n = 109), and subdivided to receive placebo or P4 on Day 4. POF size, ovulation rate, CL area, and P/AI were greater (P < 0.007) in the LF group. Pregnancy/AI in ovulated cows were lower (P = 0.05) in the SF/control group (41.5%, 17/41) compared to LF/control group (62%, 31/50) and were similar for the SF/P4 group (55.6%, 25/45) and LF/P4 group (57%, 28/49) compared to others. In summary, smaller and less vascularized POF results in less functional CL and reduces ovulatory rate and P/AI in cyclic beef cows; the long-acting P4 injection on Day 4 after timed-artificial insemination may attenuate the negative effects of small POF/CL; and postovulatory P4 supplementation improved fertility in anestrous beef cattle.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26764150</pmid><doi>10.1016/j.theriogenology.2015.12.006</doi><tpages>10</tpages></addata></record> |
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| subjects | Anestrous Animals Animals, Suckling Cattle Cell Size Embryo Estrous cycle Estrous Cycle - physiology Estrus Synchronization - methods Female Fertility - drug effects Fertility Agents, Female - administration & dosage Insemination, Artificial - veterinary Lactation - physiology Ovarian Follicle - physiology Ovulation - physiology Pregnancy Progesterone - administration & dosage Progesterone - pharmacology Uterus |
| title | Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI |
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