Mucosal Delivery of a Respiratory Syncytial Virus CTL Peptide with Enterotoxin-Based Adjuvants Elicits Protective, Immunopathogenic, and Immunoregulatory Antiviral CD8 super(+) T Cell Responses

In an effort to develop a safe and effective vaccine against respiratory syncytial virus (RSV), we used Escherichia coli heat-labile toxin (LT), and LTK63 (an LT mutant devoid of ADP-ribosyltransferase activity) to elicit murine CD8 super(+) CTL responses to an intranasally codelivered CTL peptide f...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (2), p.1106-1113
Hauptverfasser:	Simmons, C P, Hussell, T, Sparer, T, Walzl, G, Openshaw, P, Dougan, G
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8 antigen Respiratory syncytial virus
Online-Zugang:	Volltext
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