Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer

Estrogens have been implicated to be complete carcinogens in breast and gynecologic tissues. Possible mechanisms may include differential metabolism with subsequent formation of reactive oxygen species and/or a receptor-mediated pathway, which may also involve indirect modulation of intracellular re...

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Veröffentlicht in:	Carcinogenesis (New York) 2004-01, Vol.25 (1), p.3-9
Hauptverfasser:	Mobley, James A., Brueggemeier, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	2′-deoxyguanosine 8-oxo-2′-deoxyguanosine 8-oxo-dG Biological and medical sciences Blotting, Western Breast cancer Breast Neoplasms - metabolism BSO buthionine sulfoximine Catalase - metabolism Cell Line, Tumor DNA Damage ER-α ER-β estradiol Estradiol - pharmacology estrogen receptor alpha estrogen receptor beta Female G6PD glucose-6-phosphate dehydrogenase glutathione glutathione peroxidase glutathione reductase GPx GSH GSSG Gynecology. Andrology. Obstetrics Hanks buffered saline solution HBSS horse radish peroxidase type II HRP Humans Hydrogen Peroxide - pharmacology Mammary gland diseases Medical sciences Oxidative Stress oxidized glutathione PBS phosphate-suffered saline reactive oxygen species Receptors, Estrogen - physiology ROS SDS SOD sodium dodecyl sulfate superoxide dismutase TAM tamoxifen TGSH total reduced and oxidized glutathione Tumors
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