Stimulation of aniline, p-nitrophenol and N-nitrosodimethylamine metabolism in kidney by pyridine pretreatment of rabbits

Pyridine has been shown to cause liver and kidney damage in animals and in humans. In a previous study we examined the effects of pyridine on rabbit liver and lung microsomal drug-metabolizing enzymes. In this study, in vivo i.p. administration of pyridine to rabbits caused a significant 3.4-fold in...

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Veröffentlicht in:	Archives of toxicology 2000-11, Vol.74 (9), p.527-532
Hauptverfasser:	ARINC, Emel, ADALI, Orhan, GENCLER-ÖZKAN, Ayse Mine
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Aniline Hydroxylase - metabolism Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP2E1 - metabolism In Vitro Techniques Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Microsomes - drug effects Microsomes - metabolism Nitrophenols - metabolism Nitroso Compounds - metabolism Oxidoreductases, N-Demethylating - metabolism p-Nitrophenol Pyridines - pharmacology Rabbits Stimulation, Chemical Toxicology Various organic compounds
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