Human CD4 super(+) Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN- gamma , and Eradicate Tumor Cells

The implantation of small pieces of human primary lung tumor biopsy tissue into SCID mice results in a viable s.c. xenograft in which the tissue architecture, including tumor-associated leukocytes, tumor cells, and stromal cells, is preserved in a functional state. By monitoring changes in tumor vol...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-01, Vol.174 (2), p.898-906
Hauptverfasser:	Broderick, Lori, Yokota, Sandra J, Reineke, Joshua, Mathiowitz, Edith, Stewart, Carleton C, Barcos, Maurice, Kelleher, Raymond J, Bankert, Richard B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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