The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling

Aberrant expression of the oncogenic transcription factor forkhead box protein 1 (FOXP1) is a common feature of diffuse large B-cell lymphoma (DLBCL). We have combined chromatin immunoprecipitation and gene expression profiling after FOXP1 depletion with functional screening to identify targets of F...

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Veröffentlicht in:	Blood 2016-03, Vol.127 (11), p.1438-1448
Hauptverfasser:	Flori, Michael, Schmid, Corina A., Sumrall, Eric T., Tzankov, Alexandar, Law, Charity W., Robinson, Mark D., Müller, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cell Line, Tumor Chromatin Immunoprecipitation Forkhead Transcription Factors - genetics Forkhead Transcription Factors - physiology Gene Expression Profiling Gene Expression Regulation, Neoplastic Germinal Center - pathology GTP-Binding Protein alpha Subunits, G12-G13 - biosynthesis GTP-Binding Protein alpha Subunits, G12-G13 - genetics Heterografts Humans Kaplan-Meier Estimate Lymphoma, Large B-Cell, Diffuse - classification Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Mice Neoplasm Proteins - physiology Neoplasm Transplantation Prognosis Proto-Oncogene Proteins c-akt - analysis Receptors, Lysosphingolipid - biosynthesis Receptors, Lysosphingolipid - deficiency Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - physiology Repressor Proteins - genetics Repressor Proteins - physiology RNA Interference RNA, Small Interfering - genetics Signal Transduction - physiology Sphingosine-1-Phosphate Receptors
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