Progesterone suppressed vasoconstriction in human umbilical vein via reducing calcium entry

•Progesterone suppressed vasoconstrictions in HUV.•The effects were dependent on inhibition of L-type calcium channels. The aim of this study was to evaluate the actions of progesterone on human umbilical vein (HUV) from normal pregnancies and the possible underlying mechanisms involved. HUV rings w...

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Veröffentlicht in:	Steroids 2016-04, Vol.108, p.118-125
Hauptverfasser:	He, Yun, Gao, Qinqin, Han, Bing, Zhu, Xiaolin, Zhu, Di, Tao, Jianying, Chen, Jie, Xu, Zhice
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport - drug effects Calcium - metabolism Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Calcium entry Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Gene Expression Regulation - drug effects Human umbilical vein Humans Indomethacin - pharmacology Intracellular Space - drug effects Intracellular Space - metabolism omega-N-Methylarginine - pharmacology Phenylephrine - pharmacology Potassium Channel Blockers - pharmacology Pregnancy Progesterone Progesterone - pharmacology Progesterone Reductase - genetics Serotonin - pharmacology Umbilical Veins - cytology Umbilical Veins - drug effects Umbilical Veins - metabolism Umbilical Veins - physiology Vasoconstriction Vasoconstriction - drug effects
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