IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome
Objective The aim of this study was to evaluate the influence of Th17 polymorphisms on the susceptibility or severity of rheumatoid arthritis (RA) and Sjögren’s syndrome (SS). Materials and methods The study sample comprised 206 individuals of both genders divided into three groups: exclusive rheuma...
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| Veröffentlicht in: | Clinical oral investigations 2016-04, Vol.20 (3), p.495-502 |
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| creator | Carvalho, Camila Nunes do Carmo, Rodrigo Feliciano Duarte, Angela Luzia Pinto Carvalho, Alessandra Albuquerque Tavares Leão, Jair Carneiro Gueiros, Luiz Alcino |
| description | Objective
The aim of this study was to evaluate the influence of Th17 polymorphisms on the susceptibility or severity of rheumatoid arthritis (RA) and Sjögren’s syndrome (SS).
Materials and methods
The study sample comprised 206 individuals of both genders divided into three groups: exclusive rheumatoid arthritis (RA—100 patients), rheumatoid arthritis and Sjögren’s syndrome (RA/SS—31 patients), and healthy controls (C—75 individuals). All the individuals were submitted to clinical evaluation, unstimulated sialometry, and Schirmer test; some patients with RA were also submitted to minor salivary gland biopsy for definition of SS diagnosis. Saliva samples were collected for isolation of DNA and genotyping of Th17 genes; IL-17A (-197G/A) and IL-17F (7488T/C).
Results
IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to RA or secondary SS (sSS,
p
> 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS.
Conclusion
IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms are not associated with the susceptibility nor to the severity of RA and sSS in the studied population.
Clinical relevance
A better understanding of the pathogenesis of SS is demanded to an adequate treatment as well as to the development of new management strategies. |
| doi_str_mv | 10.1007/s00784-015-1540-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1774533467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1774533467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-23b52b24ccaa643facd98c01de8169f1e45c372ccfe77354404fefa03bc648fe3</originalsourceid><addsrcrecordid>eNp1kE1KxDAYhoMojo4ewI0U3LiJ5q9NuhwGRwcGRNR1SNNkpkP_TNrF7LyGF_EC3sST2GlHEcFN8kGe903yAHCG0RVGiF_7bhEMIhxCHDIEyR44woxGkHKO9_uZwCgWeASOvV8jhFnE6SEYkYhQImJ6BB7mC4j5JFBlGvTjLKirfFNUrl5lvvBBVgZuZdpCNVWWBso1K5c1me8Dj-uP96Uz5efrmw_8pkxdVZgTcGBV7s3pbh-D59nN0_QOLu5v59PJAmrGSAMJTUKSEKa1UhGjVuk0Fhrh1AgcxRYbFmrKidbWcE5DxhCzxipEEx0xYQ0dg8uht3bVS2t8I4vMa5PnqjRV6yXmnIWUbn88Bhd_0HXVurJ7XU-ROBKCdhQeKO0q752xsnZZodxGYiS3vuXgW3a-5da3JF3mfNfcJoVJfxLfgjuADIDvjsqlcb-u_rf1C_Wsiv8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774296883</pqid></control><display><type>article</type><title>IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Carvalho, Camila Nunes ; do Carmo, Rodrigo Feliciano ; Duarte, Angela Luzia Pinto ; Carvalho, Alessandra Albuquerque Tavares ; Leão, Jair Carneiro ; Gueiros, Luiz Alcino</creator><creatorcontrib>Carvalho, Camila Nunes ; do Carmo, Rodrigo Feliciano ; Duarte, Angela Luzia Pinto ; Carvalho, Alessandra Albuquerque Tavares ; Leão, Jair Carneiro ; Gueiros, Luiz Alcino</creatorcontrib><description>Objective
The aim of this study was to evaluate the influence of Th17 polymorphisms on the susceptibility or severity of rheumatoid arthritis (RA) and Sjögren’s syndrome (SS).
Materials and methods
The study sample comprised 206 individuals of both genders divided into three groups: exclusive rheumatoid arthritis (RA—100 patients), rheumatoid arthritis and Sjögren’s syndrome (RA/SS—31 patients), and healthy controls (C—75 individuals). All the individuals were submitted to clinical evaluation, unstimulated sialometry, and Schirmer test; some patients with RA were also submitted to minor salivary gland biopsy for definition of SS diagnosis. Saliva samples were collected for isolation of DNA and genotyping of Th17 genes; IL-17A (-197G/A) and IL-17F (7488T/C).
Results
IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to RA or secondary SS (sSS,
p
> 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS.
Conclusion
IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms are not associated with the susceptibility nor to the severity of RA and sSS in the studied population.
Clinical relevance
A better understanding of the pathogenesis of SS is demanded to an adequate treatment as well as to the development of new management strategies.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-015-1540-2</identifier><identifier>PMID: 26232893</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid - genetics ; Biopsy ; Case-Control Studies ; Dentistry ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukin-17 - genetics ; Male ; Medicine ; Middle Aged ; Original Article ; Polymorphism, Single Nucleotide ; Sjogren's Syndrome - genetics</subject><ispartof>Clinical oral investigations, 2016-04, Vol.20 (3), p.495-502</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-23b52b24ccaa643facd98c01de8169f1e45c372ccfe77354404fefa03bc648fe3</citedby><cites>FETCH-LOGICAL-c442t-23b52b24ccaa643facd98c01de8169f1e45c372ccfe77354404fefa03bc648fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-015-1540-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-015-1540-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26232893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho, Camila Nunes</creatorcontrib><creatorcontrib>do Carmo, Rodrigo Feliciano</creatorcontrib><creatorcontrib>Duarte, Angela Luzia Pinto</creatorcontrib><creatorcontrib>Carvalho, Alessandra Albuquerque Tavares</creatorcontrib><creatorcontrib>Leão, Jair Carneiro</creatorcontrib><creatorcontrib>Gueiros, Luiz Alcino</creatorcontrib><title>IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objective
The aim of this study was to evaluate the influence of Th17 polymorphisms on the susceptibility or severity of rheumatoid arthritis (RA) and Sjögren’s syndrome (SS).
Materials and methods
The study sample comprised 206 individuals of both genders divided into three groups: exclusive rheumatoid arthritis (RA—100 patients), rheumatoid arthritis and Sjögren’s syndrome (RA/SS—31 patients), and healthy controls (C—75 individuals). All the individuals were submitted to clinical evaluation, unstimulated sialometry, and Schirmer test; some patients with RA were also submitted to minor salivary gland biopsy for definition of SS diagnosis. Saliva samples were collected for isolation of DNA and genotyping of Th17 genes; IL-17A (-197G/A) and IL-17F (7488T/C).
Results
IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to RA or secondary SS (sSS,
p
> 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS.
Conclusion
IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms are not associated with the susceptibility nor to the severity of RA and sSS in the studied population.
Clinical relevance
A better understanding of the pathogenesis of SS is demanded to an adequate treatment as well as to the development of new management strategies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-17 - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sjogren's Syndrome - genetics</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1KxDAYhoMojo4ewI0U3LiJ5q9NuhwGRwcGRNR1SNNkpkP_TNrF7LyGF_EC3sST2GlHEcFN8kGe903yAHCG0RVGiF_7bhEMIhxCHDIEyR44woxGkHKO9_uZwCgWeASOvV8jhFnE6SEYkYhQImJ6BB7mC4j5JFBlGvTjLKirfFNUrl5lvvBBVgZuZdpCNVWWBso1K5c1me8Dj-uP96Uz5efrmw_8pkxdVZgTcGBV7s3pbh-D59nN0_QOLu5v59PJAmrGSAMJTUKSEKa1UhGjVuk0Fhrh1AgcxRYbFmrKidbWcE5DxhCzxipEEx0xYQ0dg8uht3bVS2t8I4vMa5PnqjRV6yXmnIWUbn88Bhd_0HXVurJ7XU-ROBKCdhQeKO0q752xsnZZodxGYiS3vuXgW3a-5da3JF3mfNfcJoVJfxLfgjuADIDvjsqlcb-u_rf1C_Wsiv8</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Carvalho, Camila Nunes</creator><creator>do Carmo, Rodrigo Feliciano</creator><creator>Duarte, Angela Luzia Pinto</creator><creator>Carvalho, Alessandra Albuquerque Tavares</creator><creator>Leão, Jair Carneiro</creator><creator>Gueiros, Luiz Alcino</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome</title><author>Carvalho, Camila Nunes ; do Carmo, Rodrigo Feliciano ; Duarte, Angela Luzia Pinto ; Carvalho, Alessandra Albuquerque Tavares ; Leão, Jair Carneiro ; Gueiros, Luiz Alcino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-23b52b24ccaa643facd98c01de8169f1e45c372ccfe77354404fefa03bc648fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-17 - genetics</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sjogren's Syndrome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, Camila Nunes</creatorcontrib><creatorcontrib>do Carmo, Rodrigo Feliciano</creatorcontrib><creatorcontrib>Duarte, Angela Luzia Pinto</creatorcontrib><creatorcontrib>Carvalho, Alessandra Albuquerque Tavares</creatorcontrib><creatorcontrib>Leão, Jair Carneiro</creatorcontrib><creatorcontrib>Gueiros, Luiz Alcino</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho, Camila Nunes</au><au>do Carmo, Rodrigo Feliciano</au><au>Duarte, Angela Luzia Pinto</au><au>Carvalho, Alessandra Albuquerque Tavares</au><au>Leão, Jair Carneiro</au><au>Gueiros, Luiz Alcino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>20</volume><issue>3</issue><spage>495</spage><epage>502</epage><pages>495-502</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objective
The aim of this study was to evaluate the influence of Th17 polymorphisms on the susceptibility or severity of rheumatoid arthritis (RA) and Sjögren’s syndrome (SS).
Materials and methods
The study sample comprised 206 individuals of both genders divided into three groups: exclusive rheumatoid arthritis (RA—100 patients), rheumatoid arthritis and Sjögren’s syndrome (RA/SS—31 patients), and healthy controls (C—75 individuals). All the individuals were submitted to clinical evaluation, unstimulated sialometry, and Schirmer test; some patients with RA were also submitted to minor salivary gland biopsy for definition of SS diagnosis. Saliva samples were collected for isolation of DNA and genotyping of Th17 genes; IL-17A (-197G/A) and IL-17F (7488T/C).
Results
IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to RA or secondary SS (sSS,
p
> 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS.
Conclusion
IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms are not associated with the susceptibility nor to the severity of RA and sSS in the studied population.
Clinical relevance
A better understanding of the pathogenesis of SS is demanded to an adequate treatment as well as to the development of new management strategies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26232893</pmid><doi>10.1007/s00784-015-1540-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2016-04, Vol.20 (3), p.495-502 |
| issn | 1432-6981 1436-3771 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Aged Aged, 80 and over Arthritis, Rheumatoid - genetics Biopsy Case-Control Studies Dentistry Female Genetic Predisposition to Disease Genotype Humans Interleukin-17 - genetics Male Medicine Middle Aged Original Article Polymorphism, Single Nucleotide Sjogren's Syndrome - genetics |
| title | IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome |
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