Ligand-Free Pd-Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)–C(sp2) Coupling Sequence

Ligand-Free Pd-Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)–C(sp2) Coupling Sequence

A palladium-catalyzed domino reaction via a dehydrogenative aromatization and a dual C­(sp2)–H functionalization process for one-pot synthesis of carbazoles under ligand-free conditions has been developed. On the basis of the catalytic system, carbazoles can be synthesized in moderate to good yields...

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Veröffentlicht in:Organic letters 2016-03, Vol.18 (6), p.1278-1281
Hauptverfasser: Wen, Lixian, Tang, Lin, Yang, Yu, Zha, Zhenggen, Wang, Zhiyong
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container_issue 6
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container_title Organic letters
container_volume 18
creator Wen, Lixian
Tang, Lin
Yang, Yu
Zha, Zhenggen
Wang, Zhiyong
description A palladium-catalyzed domino reaction via a dehydrogenative aromatization and a dual C­(sp2)–H functionalization process for one-pot synthesis of carbazoles under ligand-free conditions has been developed. On the basis of the catalytic system, carbazoles can be synthesized in moderate to good yields from facile arylamines and cyclic ketones, which presents straightforward and practical C­(sp2)–C­(sp2) bond formation.
doi_str_mv 10.1021/acs.orglett.6b00193
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title Ligand-Free Pd-Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)–C(sp2) Coupling Sequence
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