Colorectal Adenomas
Colon cancer begins with the malignant transformation of benign adenomas and polyps. When adenomas are large or multiple, the risk of subsequent cancer is highest. Screening techniques, although imperfect, can reduce the incidence of colorectal cancer. Since the last review of colorectal adenomas in...
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| Veröffentlicht in: | The New England journal of medicine 2016-03, Vol.374 (11), p.1065-1075 |
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| container_title | The New England journal of medicine |
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| creator | Strum, Williamson B |
| description | Colon cancer begins with the malignant transformation of benign adenomas and polyps. When adenomas are large or multiple, the risk of subsequent cancer is highest. Screening techniques, although imperfect, can reduce the incidence of colorectal cancer.
Since the last review of colorectal adenomas in the
Journal,
1
a wealth of new data has emerged that is improving our understanding of their clinical significance. In the past 10 years, several large studies, performed predominantly in the United States, have evaluated persons at average risk for colorectal adenomas. The new evidence that these studies have provided regarding the biology of adenomas, their prevalence and incidence, the relevance of risk profiles, and controversies in screening and surveillance is germane to clinical decisions and identifies potential targets for the improved management of these important premalignant lesions.
Adenomas and Sessile Serrated Polyps . . . |
| doi_str_mv | 10.1056/NEJMra1513581 |
| format | Article |
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Since the last review of colorectal adenomas in the
Journal,
1
a wealth of new data has emerged that is improving our understanding of their clinical significance. In the past 10 years, several large studies, performed predominantly in the United States, have evaluated persons at average risk for colorectal adenomas. The new evidence that these studies have provided regarding the biology of adenomas, their prevalence and incidence, the relevance of risk profiles, and controversies in screening and surveillance is germane to clinical decisions and identifies potential targets for the improved management of these important premalignant lesions.
Adenomas and Sessile Serrated Polyps . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMra1513581</identifier><identifier>PMID: 26981936</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adenoma - diagnosis ; Adenoma - ethnology ; Adenoma - pathology ; Age Factors ; Barium Sulfate ; Colon cancer ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - ethnology ; Colorectal Neoplasms - pathology ; DNA, Neoplasm - analysis ; Early Detection of Cancer - methods ; Enema ; Feces - chemistry ; Female ; Humans ; Male ; Medical screening ; Neoplasm Staging ; Occult Blood ; Polyps ; Practice Guidelines as Topic ; Risk Factors ; Tumors</subject><ispartof>The New England journal of medicine, 2016-03, Vol.374 (11), p.1065-1075</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-43239c3ca124522855da1b0b093548ffdb8604ec5fd87bacb6326e4d29919c743</citedby><cites>FETCH-LOGICAL-c310t-43239c3ca124522855da1b0b093548ffdb8604ec5fd87bacb6326e4d29919c743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMra1513581$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1774194826?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,2760,2761,26108,27929,27930,52387,54069,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26981936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Longo, Dan L</contributor><contributor>Longo, Dan L.</contributor><creatorcontrib>Strum, Williamson B</creatorcontrib><title>Colorectal Adenomas</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Colon cancer begins with the malignant transformation of benign adenomas and polyps. When adenomas are large or multiple, the risk of subsequent cancer is highest. Screening techniques, although imperfect, can reduce the incidence of colorectal cancer.
Since the last review of colorectal adenomas in the
Journal,
1
a wealth of new data has emerged that is improving our understanding of their clinical significance. In the past 10 years, several large studies, performed predominantly in the United States, have evaluated persons at average risk for colorectal adenomas. The new evidence that these studies have provided regarding the biology of adenomas, their prevalence and incidence, the relevance of risk profiles, and controversies in screening and surveillance is germane to clinical decisions and identifies potential targets for the improved management of these important premalignant lesions.
Adenomas and Sessile Serrated Polyps . . .</description><subject>Adenoma - diagnosis</subject><subject>Adenoma - ethnology</subject><subject>Adenoma - pathology</subject><subject>Age Factors</subject><subject>Barium Sulfate</subject><subject>Colon cancer</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - ethnology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DNA, Neoplasm - analysis</subject><subject>Early Detection of Cancer - methods</subject><subject>Enema</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical screening</subject><subject>Neoplasm Staging</subject><subject>Occult Blood</subject><subject>Polyps</subject><subject>Practice Guidelines as Topic</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10M1LwzAYx_EgiqvTk3gVQQQv1Tx5a3IcY74x9aLnkKYprDTNTNbD_ns7NwUFc8nlw5eHH0JngG8Ac3H7Mnt6jgY4UC5hD2XAKc0Zw2IfZRgTmbNC0RE6SqnBwwOmDtGICCVBUZGh02loQ3R2ZdqLSeW64E06Rge1aZM72f1j9H43e5s-5PPX-8fpZJ5bCniVM0qostQaIIwTIjmvDJS4xIpyJuu6KqXAzFleV7IojS0FJcKxiigFyhaMjtH1truM4aN3aaX9IlnXtqZzoU8aimIICyk39PIPbUIfu-G6LwWKSSIGlW-VjSGl6Gq9jAtv4loD1pu19K-1Bn--q_ald9WP_p5nAFdb4H3SnWv8P6FPwMRstg</recordid><startdate>20160317</startdate><enddate>20160317</enddate><creator>Strum, Williamson B</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160317</creationdate><title>Colorectal Adenomas</title><author>Strum, Williamson B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-43239c3ca124522855da1b0b093548ffdb8604ec5fd87bacb6326e4d29919c743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenoma - diagnosis</topic><topic>Adenoma - ethnology</topic><topic>Adenoma - pathology</topic><topic>Age Factors</topic><topic>Barium Sulfate</topic><topic>Colon cancer</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - ethnology</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DNA, Neoplasm - analysis</topic><topic>Early Detection of Cancer - methods</topic><topic>Enema</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical screening</topic><topic>Neoplasm Staging</topic><topic>Occult Blood</topic><topic>Polyps</topic><topic>Practice Guidelines as Topic</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strum, Williamson B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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When adenomas are large or multiple, the risk of subsequent cancer is highest. Screening techniques, although imperfect, can reduce the incidence of colorectal cancer.
Since the last review of colorectal adenomas in the
Journal,
1
a wealth of new data has emerged that is improving our understanding of their clinical significance. In the past 10 years, several large studies, performed predominantly in the United States, have evaluated persons at average risk for colorectal adenomas. The new evidence that these studies have provided regarding the biology of adenomas, their prevalence and incidence, the relevance of risk profiles, and controversies in screening and surveillance is germane to clinical decisions and identifies potential targets for the improved management of these important premalignant lesions.
Adenomas and Sessile Serrated Polyps . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26981936</pmid><doi>10.1056/NEJMra1513581</doi><tpages>11</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 2016-03, Vol.374 (11), p.1065-1075 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1774526884 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adenoma - diagnosis Adenoma - ethnology Adenoma - pathology Age Factors Barium Sulfate Colon cancer Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - ethnology Colorectal Neoplasms - pathology DNA, Neoplasm - analysis Early Detection of Cancer - methods Enema Feces - chemistry Female Humans Male Medical screening Neoplasm Staging Occult Blood Polyps Practice Guidelines as Topic Risk Factors Tumors |
| title | Colorectal Adenomas |
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