$A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom$

A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom

Several spider neurotoxins are known to show highly selective effects on nervous tissues. Intracerebral injection into rats of spider venom from Scaptocosa raptoria, prevents seizures induced by convulsant agents. Injection of phenytoin (390 pmol/200 nl), muscimol (90 pmol/200 nl), baclofen (500 pmo...

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Veröffentlicht in:	Neuroscience letters 2004-11, Vol.371 (2), p.171-175
Hauptverfasser:	Mussi-Ribeiro, Alessandra, Miranda, Antonio, Gobbo-Netto, Leonardo, Peporine Lopes, Norberto, dos Santos, Wagner Ferreira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsant Anticonvulsants - isolation & purification Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Bicuculline Biological and medical sciences Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology GABA agonists Lycosidae Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Wistar Scaptocosa raptoria Seizures Seizures - prevention & control Spider venom Spider Venoms - isolation & purification Spider Venoms - pharmacology Spider Venoms - therapeutic use Substantia Nigra - drug effects Substantia Nigra - physiology Vertebrates: nervous system and sense organs
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