Immune effects and mechanisms of action of CpG motifs
Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed ‘CpG motifs’. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize ‘CpG motifs’ as foreign, and trigg...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2000-11, Vol.19 (6), p.618-622 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 622 |
|---|---|
| container_issue | 6 |
| container_start_page | 618 |
| container_title | Vaccine |
| container_volume | 19 |
| creator | Krieg, Arthur M |
| description | Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed ‘CpG motifs’. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize ‘CpG motifs’ as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic diseases. |
| doi_str_mv | 10.1016/S0264-410X(00)00249-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17741664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X00002498</els_id><sourcerecordid>17741664</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-dd1ad8e8a03b38dd10d213c53558b26b8aa21bd6f07725ac10fa30b45a640a963</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRbK3-BCUgiB6iM5tssjmJFK2FggcVvC2T_cCVfNRsKvjvTT_Qo6eZgeedGR7GThGuETC7eQaepXGK8HYJcAXA0yKWe2yMMk9iLlDus_EvMmJHIXwAgEiwOGQjRCggRz5mYl7Xq8ZG1jmr-xBRY6La6ndqfKhD1LqIdO_bZt1Nl7OobnvvwjE7cFQFe7KrE_b6cP8yfYwXT7P59G4R65RDHxuDZKSVBEmZyGECwzHRIhFCljwrJRHH0mQO8pwL0giOEihTQVkKVGTJhF1s9y679nNlQ69qH7StKmpsuwoK8zzFLEsHUGxB3bUhdNapZedr6r4Vglr7Uhtfai1DAaiNLyWH3NnuwKqsrflL7QQNwPkOoKCpch012odfTgocVg7U7Zayg4wvbzsVtLeNtsZ3g1ZlWv_PIz8eSIUw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17741664</pqid></control><display><type>article</type><title>Immune effects and mechanisms of action of CpG motifs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Krieg, Arthur M</creator><contributor>Nara, P ; Rabinovich, R ; Weniger, B (eds) ; Martone, W</contributor><creatorcontrib>Krieg, Arthur M ; Nara, P ; Rabinovich, R ; Weniger, B (eds) ; Martone, W</creatorcontrib><description>Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed ‘CpG motifs’. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize ‘CpG motifs’ as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic diseases.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(00)00249-8</identifier><identifier>PMID: 11090712</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Adjuvants, Immunologic - toxicity ; Animals ; Applied microbiology ; Biological and medical sciences ; CpG Islands - immunology ; CpG motifs ; cytidine phosphate guanosine ; Dendritic cell ; dinucleotides ; DNA ; DNA, Bacterial - immunology ; Fundamental and applied biological sciences. Psychology ; Immunity, Active ; Immunity, Cellular ; Immunotherapy ; Innate immunity ; Mice ; Microbiology ; oligodeoxyribonucleotides ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, DNA - immunology ; Vaccines, DNA - therapeutic use ; Vaccines, DNA - toxicity</subject><ispartof>Vaccine, 2000-11, Vol.19 (6), p.618-622</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-dd1ad8e8a03b38dd10d213c53558b26b8aa21bd6f07725ac10fa30b45a640a963</citedby><cites>FETCH-LOGICAL-c420t-dd1ad8e8a03b38dd10d213c53558b26b8aa21bd6f07725ac10fa30b45a640a963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X00002498$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=851410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11090712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nara, P</contributor><contributor>Rabinovich, R</contributor><contributor>Weniger, B (eds)</contributor><contributor>Martone, W</contributor><creatorcontrib>Krieg, Arthur M</creatorcontrib><title>Immune effects and mechanisms of action of CpG motifs</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed ‘CpG motifs’. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize ‘CpG motifs’ as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic diseases.</description><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Adjuvants, Immunologic - toxicity</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>CpG Islands - immunology</subject><subject>CpG motifs</subject><subject>cytidine phosphate guanosine</subject><subject>Dendritic cell</subject><subject>dinucleotides</subject><subject>DNA</subject><subject>DNA, Bacterial - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity, Active</subject><subject>Immunity, Cellular</subject><subject>Immunotherapy</subject><subject>Innate immunity</subject><subject>Mice</subject><subject>Microbiology</subject><subject>oligodeoxyribonucleotides</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, DNA - immunology</subject><subject>Vaccines, DNA - therapeutic use</subject><subject>Vaccines, DNA - toxicity</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-BCUgiB6iM5tssjmJFK2FggcVvC2T_cCVfNRsKvjvTT_Qo6eZgeedGR7GThGuETC7eQaepXGK8HYJcAXA0yKWe2yMMk9iLlDus_EvMmJHIXwAgEiwOGQjRCggRz5mYl7Xq8ZG1jmr-xBRY6La6ndqfKhD1LqIdO_bZt1Nl7OobnvvwjE7cFQFe7KrE_b6cP8yfYwXT7P59G4R65RDHxuDZKSVBEmZyGECwzHRIhFCljwrJRHH0mQO8pwL0giOEihTQVkKVGTJhF1s9y679nNlQ69qH7StKmpsuwoK8zzFLEsHUGxB3bUhdNapZedr6r4Vglr7Uhtfai1DAaiNLyWH3NnuwKqsrflL7QQNwPkOoKCpch012odfTgocVg7U7Zayg4wvbzsVtLeNtsZ3g1ZlWv_PIz8eSIUw</recordid><startdate>20001108</startdate><enddate>20001108</enddate><creator>Krieg, Arthur M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20001108</creationdate><title>Immune effects and mechanisms of action of CpG motifs</title><author>Krieg, Arthur M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-dd1ad8e8a03b38dd10d213c53558b26b8aa21bd6f07725ac10fa30b45a640a963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Adjuvants, Immunologic - toxicity</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>CpG Islands - immunology</topic><topic>CpG motifs</topic><topic>cytidine phosphate guanosine</topic><topic>Dendritic cell</topic><topic>dinucleotides</topic><topic>DNA</topic><topic>DNA, Bacterial - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunity, Active</topic><topic>Immunity, Cellular</topic><topic>Immunotherapy</topic><topic>Innate immunity</topic><topic>Mice</topic><topic>Microbiology</topic><topic>oligodeoxyribonucleotides</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, DNA - immunology</topic><topic>Vaccines, DNA - therapeutic use</topic><topic>Vaccines, DNA - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krieg, Arthur M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krieg, Arthur M</au><au>Nara, P</au><au>Rabinovich, R</au><au>Weniger, B (eds)</au><au>Martone, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune effects and mechanisms of action of CpG motifs</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2000-11-08</date><risdate>2000</risdate><volume>19</volume><issue>6</issue><spage>618</spage><epage>622</epage><pages>618-622</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed ‘CpG motifs’. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize ‘CpG motifs’ as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic diseases.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11090712</pmid><doi>10.1016/S0264-410X(00)00249-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2000-11, Vol.19 (6), p.618-622 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17741664 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adjuvants, Immunologic - therapeutic use Adjuvants, Immunologic - toxicity Animals Applied microbiology Biological and medical sciences CpG Islands - immunology CpG motifs cytidine phosphate guanosine Dendritic cell dinucleotides DNA DNA, Bacterial - immunology Fundamental and applied biological sciences. Psychology Immunity, Active Immunity, Cellular Immunotherapy Innate immunity Mice Microbiology oligodeoxyribonucleotides Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Vaccines, DNA - toxicity |
| title | Immune effects and mechanisms of action of CpG motifs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A39%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20effects%20and%20mechanisms%20of%20action%20of%20CpG%20motifs&rft.jtitle=Vaccine&rft.au=Krieg,%20Arthur%20M&rft.date=2000-11-08&rft.volume=19&rft.issue=6&rft.spage=618&rft.epage=622&rft.pages=618-622&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/S0264-410X(00)00249-8&rft_dat=%3Cproquest_cross%3E17741664%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17741664&rft_id=info:pmid/11090712&rft_els_id=S0264410X00002498&rfr_iscdi=true |