Real-time functional characterization of cationic amino acid transporters using a new FRET sensor

L-arginine is a semi-essential amino acid that serves as precursor for the production of urea, nitric oxide (NO), polyamines, and other biologically important metabolites. Hence, a fast and reliable assessment of its intracellular concentration changes is highly desirable. Here, we report on a genet...

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Veröffentlicht in:	Pflügers Archiv 2016-04, Vol.468 (4), p.563-572
Hauptverfasser:	Vanoaica, Liviu, Behera, Alok, Camargo, Simone M. R., Forster, Ian C., Verrey, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biomedical and Life Sciences Biomedicine Biosensing Techniques - methods Cationic Amino Acid Transporter 1 - metabolism Cell Biology Fluorescence Resonance Energy Transfer - methods HEK293 Cells Human Physiology Humans Ion Channels Membrane Potentials Molecular Medicine Neurosciences Receptors Receptors and Transporters Repressor Proteins - chemistry Repressor Proteins - metabolism Trans-Activators - chemistry Trans-Activators - metabolism
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