Targeted Gene Disruption Reveals the Role of the Cysteinyl Leukotriene 2 Receptor in Increased Vascular Permeability and in Bleomycin-induced Pulmonary Fibrosis in Mice

The cysteinyl leukotrienes (cys-LTs) mediate both acute and chronic inflammatory responses in mice, as demonstrated by the attenuation of the IgE/antigen-mediated increase in microvascular permeability and of bleomycin-induced pulmonary fibrosis, respectively, in a strain with targeted disruption of...

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Veröffentlicht in:	The Journal of biological chemistry 2004-10, Vol.279 (44), p.46129-46134
Hauptverfasser:	Beller, Thomas C, Maekawa, Akiko, Friend, Daniel S, Austen, K Frank, Kanaoka, Yoshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - pharmacology Capillary Permeability Gene Targeting Male Mast Cells - physiology Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Passive Cutaneous Anaphylaxis Pulmonary Fibrosis - chemically induced Receptors, Leukotriene - genetics Receptors, Leukotriene - physiology RNA, Messenger - analysis
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