Immunomodulation of the Human Prion Peptide 106–126 Aggregation

Site-directed monoclonal antibodies (mAbs) may interact with their antigens, leading to stabilization, refolding, and suppression of aggregation. In the following study, we show that mAbs raised against the peptide 106–126 of human prion protein (PrP 106–126) modulate the conformational changes occu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-01, Vol.280 (1), p.115-120
Hauptverfasser:	Hanan, Eilat, Goren, Orna, Eshkenazy, Marcel, Solomon, Beka
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Amyloid - chemistry Amyloid - drug effects Animals Antibodies, Monoclonal Cell Survival - drug effects Humans immunomodulation Mice Mice, Inbred BALB C monoclonal antibody neurotoxicity Neurotoxins - toxicity PC12 Cells Peptide Fragments - chemistry Peptide Fragments - immunology Peptide Fragments - toxicity prion peptide Prions - chemistry Prions - immunology Prions - toxicity Protein Conformation Protein Denaturation Rats
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