Differential responses of Chinese hamster mutagen sensitive cell lines to low and high concentrations of calicheamicin and neocarzinostatin

To shed light on the mechanism underlying the cellular response to the radiomimetic agents calicheamicin Y 1 1 (CAL) and neocarzinostatin (NCS), several hamster cell mutants defective in different DNA repair pathways were used. Two X-ray sensitive Chinese hamster V79 mutant cell lines, XR-V9B and V-...

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Veröffentlicht in:	Mutation research 2000-11, Vol.471 (1), p.95-105
Hauptverfasser:	van Duijn-Goedhart, A, Zdzienicka, M.Z, Sankaranarayanan, K, van Buul, P.P.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - toxicity Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - toxicity Biological and medical sciences Biological effects of radiation Calicheamicin Cell Line Cell Survival - drug effects Chinese hamster Chromosome Aberrations Cricetinae Cricetulus - genetics DNA Damage - drug effects Dose-Response Relationship, Drug Enediynes Fundamental and applied biological sciences. Psychology G2 Phase - drug effects Ionizing radiations Micronuclei, Chromosome-Defective - drug effects Micronucleus Tests Mutagen sensitive cell lines Mutagens - administration & dosage Mutagens - toxicity Neocarzinostatin Radiation Tolerance Tissues, organs and organisms biophysics zinostatin Zinostatin - administration & dosage Zinostatin - toxicity
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