Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment

In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is expressed on the plasma as well as vesicular membranes and critically influences metastatic behavior. The soluble, cleaved N-terminal domain of V-ATPase a2 isoform is associated with in vitro induction of tumorigenic characteris...

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Veröffentlicht in:	Oncogene 2016-02, Vol.35 (8), p.1058-1065
Hauptverfasser:	Katara, G K, Kulshrestha, A, Jaiswal, M K, Pamarthy, S, Gilman-Sachs, A, Beaman, K D
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 38 42/35 631/67/327 Adenosine triphosphatase Animals Apoptosis Arginase Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - immunology Cancer Cancer cells Carcinogenesis CD11b antigen CD11c antigen Cell activation Cell Biology Cell proliferation Cellular biology Disease Models, Animal Enzymes Female Flow cytometry Genetic aspects Growth Growth factors H+-transporting ATPase Health aspects Human Genetics Immune system Interleukin 10 Internal Medicine Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Lymphocytes T Macrophages Mammary gland Mannose Matrix metalloproteinase Medicine Medicine & Public Health Metalloproteinase Metastases Mice Mice, Inbred BALB C Oncology Properties Protein expression short-communication Transforming growth factor-b Tumor cells Tumor Cells, Cultured Tumor Microenvironment Tumor-infiltrating lymphocytes Tumorigenesis Tumors Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuolar Proton-Translocating ATPases - metabolism Vascular endothelial growth factor
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