Genetic Mapping of Activity Determinants within Cellular Prion Proteins: N-terminal modules in PrP super(C) offset pro-apoptotic activity of the Doppel helix B/B' region

The PrP-like Doppel (Dpl) protein causes apoptotic death of cerebellar neurons in transgenic mice, a process prevented by expression of the wild type (wt) cellular prion protein, PrP super(C). Internally deleted forms of PrP super(C) resembling Dpl such as PrPdelta32-121 produce a similar PrP super(...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (53), p.55443-55454
Hauptverfasser:	Drisaldi, Bettina, Coomaraswamy, Janaky, Mastrangelo, Peter, Strome, Bob, Yang, Jing, Watts, Joel C, Chishti, MAzhar, Marvi, Melissa, Windl, Otto, Ahrens, Rosemary, Major, Francois, Sy, Man-Sun, Kretzschmar, Hans, Fraser, Paul E, Mount, Howard TJ, Westaway, David
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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