State transition analysis of spontaneous branch migration of the Holliday junction by photon-based single-molecule fluorescence resonance energy transfer

Branch migration of Holliday junction (HJ) DNA in solution is a spontaneous conformational change between multiple discrete states. We applied single-molecule fluorescence resonance energy transfer (smFRET) measurement to three-state branch migration. The photon-based variational Bayes-hidden Markov...

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Veröffentlicht in:	Biophysical chemistry 2016-02, Vol.209, p.21-27
Hauptverfasser:	Okamoto, Kenji, Sako, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Conformational dynamics DNA, Cruciform - chemistry Fluorescence Resonance Energy Transfer - methods FRET Hidden Markov model Kinetics Photons Single photon counting Single-molecule measurement Variational Bayes
Online-Zugang:	Volltext
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