Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy

Abstract Objective Sublingual immunotherapy (SLIT) is proven to be very effective in the treatment of allergic rhinitis (AR), but its regulatory mechanism and biomarkers for predicting efficacy are still unknown. Osteopontin (OPN), as a recently described Th2 inflammation related protein, plays key...

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Veröffentlicht in:	International journal of pediatric otorhinolaryngology 2016-02, Vol.81, p.15-20
Hauptverfasser:	Wang, Chunrui, Wang, Kai, Liu, Shaoting, Qin, Xiaowei, Chen, Kewa, Zhang, Tianhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergens - immunology Allergic rhinitis Animals Biomarkers - blood Child Child, Preschool Cytokines - metabolism Dermatophagoides pteronyssinus Enzyme-Linked Immunosorbent Assay Female Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Male Osteopontin Osteopontin - blood Otolaryngology Pediatrics Pyroglyphidae - immunology Rhinitis, Allergic - drug therapy Rhinitis, Allergic - immunology Sublingual immunotherapy Sublingual Immunotherapy - methods Th2 cytokines Treatment Outcome
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