Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking: e0148181

The NS5B polymerase is one of the most attractive targets for developing new drugs to block Hepatitis C virus (HCV) infection. We describe the discovery of novel potent HCV NS5B polymerase inhibitors by employing a virtual screening (VS) approach, which is based on random forest (RB-VS), e-pharmacop...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2)
Hauptverfasser:	Wei, Yu, Li, Jinlong, Qing, Jie, Huang, Mingjie, Wu, Ming, Gao, Fenghua, Li, Dongmei, Hong, Zhangyong, Kong, Lingbao, Huang, Weiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatitis C virus
Online-Zugang:	Volltext
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