Dynamic modeling of bone metastasis, microenvironment and therapy: Integrating parathyroid hormone (PTH) effect, anti-resorptive and anti-cancer therapy

Bone is a common site for the development of metastasis, as its microenvironment provides the necessary conditions for the growth and proliferation of cancer cells. Several mathematical models to describe the bone remodeling process and how osteoclasts and osteoblasts coupled action ensures bone hom...

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Veröffentlicht in:Journal of theoretical biology 2016-02, Vol.391, p.1-12
Hauptverfasser: Coelho, Rui Moura, Lemos, João Miranda, Alho, Irina, Valério, Duarte, Ferreira, Arlindo R, Costa, Luís, Vinga, Susana
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Sprache:eng
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