Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia

We conducted a comprehensive analysis of 28 recurrently mutated genes in acute myeloid leukemia (AML) in 271 patients with de novo AML. Co-mutations were frequently detected in the intermediate cytogenetic risk group, at an average of 2.76 co-mutations per patient. When assessing the prognostic impa...

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Veröffentlicht in:	Leukemia 2016-03, Vol.30 (3), p.545-554
Hauptverfasser:	Wakita, S, Yamaguchi, H, Ueki, T, Usuki, K, Kurosawa, S, Kobayashi, Y, Kawata, E, Tajika, K, Gomi, S, Koizumi, M, Fujiwara, Y, Yui, S, Fukunaga, K, Ryotokuji, T, Hirakawa, T, Arai, K, Kitano, T, Kosaka, F, Tamai, H, Nakayama, K, Fukuda, T, Inokuchi, K
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/208/1405 631/208/737 631/67/68 692/699/67/1990/283/1897 692/700/1750 Abnormalities Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Cancer Research CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Chromosome Aberrations Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Critical Care Medicine Cytogenetic Analysis Cytogenetics DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Flt3 protein fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - metabolism Gene Expression Gene mutations Genes Genetic abnormalities Health aspects Hematology Humans Identification and classification Intensive Internal Medicine Kinases Leukemia Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Medical prognosis Medicine Medicine & Public Health Middle Aged Multivariate analysis Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology original-article Patients Prognosis Protein-tyrosine kinase Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Recurrence Retrospective Studies Risk Survival Analysis Transplantation Tyrosine
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