Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

Abstract LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2−/− ) mice. LRRK2−/− mice had significantly h...

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Veröffentlicht in:	Journal of neuroimmunology 2016-03, Vol.292, p.1-8
Hauptverfasser:	Kubo, Makoto, Nagashima, Ryuichi, Ohta, Etsuro, Maekawa, Tatsunori, Isobe, Yumiko, Kurihara, Mitsue, Eshima, Koji, Iwabuchi, Kazuya, Sasaoka, Toshikuni, Azuma, Sadahiro, Melrose, Heather L, Farrer, Matthew J, Obata, Fumiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Allergy and Immunology Animals Antigens, CD - metabolism B cell receptor signaling B-Lymphocytes - classification B-Lymphocytes - metabolism B1 cell B2 cell Enzyme-Linked Immunosorbent Assay Ficoll - analogs & derivatives Ficoll - immunology Flow Cytometry Homeostasis - genetics IgA Immunoglobulin A - blood Leucine-rich repeat kinase 2 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 MAP Kinase Signaling System - immunology Mice Mice, Inbred C57BL Mice, Transgenic Neurology Peritoneal Cavity - cytology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism Signal Transduction - genetics Signal Transduction - physiology Spleen - cytology TI antigen Transforming Growth Factor beta1 - blood Trinitrobenzenes - immunology
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