Haplotype-resolved genome sequencing: experimental methods and applications

Key Points Haplotypes link together (that is, 'phase') groups of genetic variants that co-occur on single chromosomes. Although haplotypes have an important role in clinical genetics and association studies, they are not typically obtained by contemporary genotyping or sequencing technolog...

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Veröffentlicht in:	Nature reviews. Genetics 2015-06, Vol.16 (6), p.344-358
Hauptverfasser:	Snyder, Matthew W., Adey, Andrew, Kitzman, Jacob O., Shendure, Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/1647/514/2254 631/208/212/2301 631/208/726/649 631/208/728 Agriculture Animal Genetics and Genomics Animals Biomedicine Cancer Research Computer Simulation DNA sequencing Gene Function Genome, Human Haplotypes High-Throughput Nucleotide Sequencing Human Genetics Humans Identification and classification Linkage Disequilibrium Methods Models, Genetic Nucleotide sequencing review-article Sequence Analysis, DNA
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