Irradiation‐induced localization of IL‐12‐expressing mesenchymal stem cells to enhance the curative effect in murine metastatic hepatoma

Irradiation in conjunction with gene therapy is considered for efficient cancer treatment. Mesenchymal stem cells (MSCs), due to their irradiation‐promotable tumor tropism, are ideal delivery vehicles for gene therapy. In this study, we investigated whether treatment with radiation and interleukin (...

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Veröffentlicht in:	International journal of cancer 2015-08, Vol.137 (3), p.721-730
Hauptverfasser:	Jeong, Keun‐Yeong, Lee, Eun‐Jung, Kim, Su Jin, Yang, Seung‐Hyun, Sung, Young Chul, Seong, Jinsil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis - radiation effects Cancer Cell Line, Tumor Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cytokines Cytotoxicity Disease Models, Animal Gene Expression Regulation, Neoplastic - radiation effects Gene therapy Genetic Therapy HCC IL‐12 Interleukin-12 - genetics Interleukin-12 - metabolism irradiation Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - therapy Localization Male Medical research mesenchymal stem cell Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - radiation effects Metastasis Mice Monocytes - metabolism Monocytes - radiation effects Neoplasm Metastasis Radiation, Ionizing Radiotherapy Stem cells T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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