Prevalence in the USA of rilpivirine resistance-associated mutations in clinical samples and effects on phenotypic susceptibility to rilpivirine and etravirine

The prevalence of rilpivirine resistance-associated mutations (RAMs) in the USA, and their effect on phenotypic susceptibility to rilpivirine and etravirine, was evaluated in clinical samples from HIV-1-infected patients. In total, 15,991 samples submitted to Monogram Biosciences (South San Francisc...

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Veröffentlicht in:	Antiviral therapy 2014-01, Vol.19 (8), p.819-823
Hauptverfasser:	Picchio, Gaston R, Rimsky, Laurence T, Van Eygen, Veerle, Haddad, Mojgan, Napolitano, Laura A, Vingerhoets, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Drug Resistance, Viral Genotype HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Humans Microbial Sensitivity Tests Mutation Nitriles - pharmacology Nitriles - therapeutic use Prevalence Pyridazines - pharmacology Pyrimidines - pharmacology Pyrimidines - therapeutic use Rilpivirine United States - epidemiology
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