Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity

Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that shows enhanced antiretroviral effect and reduced plasma tenofovir exposures at approximately one-tenth the clinically approved dose of tenofovir disoproxil fumarate (TDF). Tenofovir released from TDF undergoes active renal secretion vi...

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Veröffentlicht in:	Antiviral therapy 2014-01, Vol.19 (7), p.687-692
Hauptverfasser:	Bam, Rujuta A, Yant, Stephen R, Cihlar, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemistry Adenine - metabolism Adenine - pharmacology Antiviral Agents - chemistry Antiviral Agents - metabolism Antiviral Agents - pharmacology Biological Transport Cell Line Cells, Cultured Gene Expression Humans Kidney Tubules, Proximal - metabolism Organic Anion Transport Protein 1 - genetics Organic Anion Transport Protein 1 - metabolism Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism
Online-Zugang:	Volltext
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