Ischemic preconditioning protects the brain against injury via inhibiting CaMKII–nNOS signaling pathway

Abstract Although studies have shown that cerebral ischemic preconditioning (IPC) can ameliorate ischemia/reperfusion (I/R) induced brain damage, but its precise mechanisms remain unknown. Therefore, the aim of this study was to investigate the neuroprotective mechanisms of IPC against ischemic brai...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2016-03, Vol.1634, p.140-149
Hauptverfasser:	Wang, Mei, Qi, Da-Shi, Zhou, Cui, Han, Dong, Li, Pei-Pei, Zhang, Fang, Zhou, Xiao-Yan, Han, Meng, Di, Jie-Hui, Ye, Jun-Song, Yu, Hong-Min, Song, Yuan-Jian, Zhang, Guang-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Animals Apoptosis - drug effects Brain Ischemia - metabolism c-Jun CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CaMKII Disks Large Homolog 4 Protein Fas Ligand Protein - metabolism FasL Intracellular Signaling Peptides and Proteins - metabolism Ischemic Preconditioning JNK Mitogen-Activated Protein Kinases - metabolism Male Membrane Proteins - metabolism Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Nitric Oxide Synthase Type I - metabolism nNOS Phosphorylation PSD95 Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!