Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains: e1005362

The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag). The structure of the JC virus T-ag origin-binding domain (OBD) was recently solved by X-ray crystallography. This structure revealed that the OBD...

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Veröffentlicht in:	PLoS pathogens 2016-01, Vol.12 (2)
Hauptverfasser:	Meinke, Gretchen, Phelan, Paul J, Shin, Jong, Gagnon, David, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Data collection Deoxyribonucleic acid DNA Experiments Genomes JC virus Mutation Polyomavirus Studies Viruses
Online-Zugang:	Volltext
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