Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma
Abstract Purpose The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors. Methods In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for trypt...
Gespeichert in:
| Veröffentlicht in: | Clinical therapeutics 2016-02, Vol.38 (2), p.297-301 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 301 |
|---|---|
| container_issue | 2 |
| container_start_page | 297 |
| container_title | Clinical therapeutics |
| container_volume | 38 |
| creator | Vyzoukaki, Rodanthi, MD Tsirakis, George, MD, PhD Pappa, Constantina A., MD, PhD Androulakis, Nikolaos, MSc Kokonozaki, Maria, MD Tzardi, Maria, MD, PhD Alexandrakis, Michael G., MD, PhD |
| description | Abstract Purpose The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors. Methods In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for tryptase and serum levels of matrix metalloproteinase 9 (MMP-9), angiopoietin 2 (ANGIOP-2), and angiogenin (ANG) with ELISA. Findings Levels of MCD, ANGIOP-2, and ANG were significantly higher in MM patients compared with the control group. The MMP-9 level was higher in MM patients compared with the control group but without statistical significance. All values were increasing in parallel with clinical stages. Furthermore, MCD correlated positively with MMP-9, ANGIOP-2, and ANG. Implications MCs participate in the angiogenic processes of MM, with complex implicated mechanisms. This interplay between MCs and the other participants favors angiogenesis and MM growth. |
| doi_str_mv | 10.1016/j.clinthera.2015.11.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1773831693</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149291815013181</els_id><sourcerecordid>1773831693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-770325e629887f0d39bfa31582782526cf18ded2e3d86f308a906a26148b9da03</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhL0AkLlwSPHbijwvSKnxKrUACBDfL60xab7PxYnsr5d_jaJci9dTTjORnXuudd4riFZAaCPC329qObkrXGExNCbQ1QE0ofVSsQApVATS_HxcrAo2qqAJ5VjyLcUsIYaqlT4szykVD8sOqsJ0PAUeTnJ9KP5SXJqayw3Es3-MUXZrLXy5dl-vpyvkrnJwtuzn5GzdhLN1UfsuDOKV4omxyt1heHsbk9mNuZhz9zjwvngxmjPjiVM-Lnx8__Og-VxdfP33p1heVbaRIlRCE0RY5VVKKgfRMbQbDoJVUSNpSbgeQPfYUWS_5wIg0inBDOTRyo3pD2Hnx5qi7D_7PAWPSOxdt9mIm9IeoQQgmGXDFHoByQbiQckFf30O3_hCmbGSheCtBKciUOFI2-BgDDnof3M6EWQPRS2R6q-8i00tkGkDnyPLky5P-YbPD_m7uX0YZWB8BzLu7dRh0tHnpFnsX0Cbde_eAT97d01g4Z814gzPG_450pJro78vlLIcDLQGWC_sLdj6-4Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1766581991</pqid></control><display><type>article</type><title>Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central</source><creator>Vyzoukaki, Rodanthi, MD ; Tsirakis, George, MD, PhD ; Pappa, Constantina A., MD, PhD ; Androulakis, Nikolaos, MSc ; Kokonozaki, Maria, MD ; Tzardi, Maria, MD, PhD ; Alexandrakis, Michael G., MD, PhD</creator><creatorcontrib>Vyzoukaki, Rodanthi, MD ; Tsirakis, George, MD, PhD ; Pappa, Constantina A., MD, PhD ; Androulakis, Nikolaos, MSc ; Kokonozaki, Maria, MD ; Tzardi, Maria, MD, PhD ; Alexandrakis, Michael G., MD, PhD</creatorcontrib><description>Abstract Purpose The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors. Methods In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for tryptase and serum levels of matrix metalloproteinase 9 (MMP-9), angiopoietin 2 (ANGIOP-2), and angiogenin (ANG) with ELISA. Findings Levels of MCD, ANGIOP-2, and ANG were significantly higher in MM patients compared with the control group. The MMP-9 level was higher in MM patients compared with the control group but without statistical significance. All values were increasing in parallel with clinical stages. Furthermore, MCD correlated positively with MMP-9, ANGIOP-2, and ANG. Implications MCs participate in the angiogenic processes of MM, with complex implicated mechanisms. This interplay between MCs and the other participants favors angiogenesis and MM growth.</description><identifier>ISSN: 0149-2918</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.clinthera.2015.11.022</identifier><identifier>PMID: 26740291</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Angiogenesis ; Cell Count ; Conflicts of interest ; cytokines ; Cytokines - metabolism ; Disease ; Female ; Humans ; Internal Medicine ; Male ; mast cells ; Mast Cells - metabolism ; Matrix Metalloproteinase 9 ; Medical Education ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - pathology ; Neovascularization, Pathologic - metabolism ; Ribonuclease, Pancreatic - metabolism ; Statistical analysis ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Clinical therapeutics, 2016-02, Vol.38 (2), p.297-301</ispartof><rights>Elsevier HS Journals, Inc.</rights><rights>2016 Elsevier HS Journals, Inc.</rights><rights>Copyright © 2016 Elsevier HS Journals, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-770325e629887f0d39bfa31582782526cf18ded2e3d86f308a906a26148b9da03</citedby><cites>FETCH-LOGICAL-c487t-770325e629887f0d39bfa31582782526cf18ded2e3d86f308a906a26148b9da03</cites><orcidid>0000-0003-1297-6409 ; 0000-0001-8842-2360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1766581991?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26740291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vyzoukaki, Rodanthi, MD</creatorcontrib><creatorcontrib>Tsirakis, George, MD, PhD</creatorcontrib><creatorcontrib>Pappa, Constantina A., MD, PhD</creatorcontrib><creatorcontrib>Androulakis, Nikolaos, MSc</creatorcontrib><creatorcontrib>Kokonozaki, Maria, MD</creatorcontrib><creatorcontrib>Tzardi, Maria, MD, PhD</creatorcontrib><creatorcontrib>Alexandrakis, Michael G., MD, PhD</creatorcontrib><title>Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma</title><title>Clinical therapeutics</title><addtitle>Clin Ther</addtitle><description>Abstract Purpose The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors. Methods In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for tryptase and serum levels of matrix metalloproteinase 9 (MMP-9), angiopoietin 2 (ANGIOP-2), and angiogenin (ANG) with ELISA. Findings Levels of MCD, ANGIOP-2, and ANG were significantly higher in MM patients compared with the control group. The MMP-9 level was higher in MM patients compared with the control group but without statistical significance. All values were increasing in parallel with clinical stages. Furthermore, MCD correlated positively with MMP-9, ANGIOP-2, and ANG. Implications MCs participate in the angiogenic processes of MM, with complex implicated mechanisms. This interplay between MCs and the other participants favors angiogenesis and MM growth.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiogenesis</subject><subject>Cell Count</subject><subject>Conflicts of interest</subject><subject>cytokines</subject><subject>Cytokines - metabolism</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>mast cells</subject><subject>Mast Cells - metabolism</subject><subject>Matrix Metalloproteinase 9</subject><subject>Medical Education</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - pathology</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Ribonuclease, Pancreatic - metabolism</subject><subject>Statistical analysis</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>0149-2918</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk1v1DAQhiMEokvhL0AkLlwSPHbijwvSKnxKrUACBDfL60xab7PxYnsr5d_jaJci9dTTjORnXuudd4riFZAaCPC329qObkrXGExNCbQ1QE0ofVSsQApVATS_HxcrAo2qqAJ5VjyLcUsIYaqlT4szykVD8sOqsJ0PAUeTnJ9KP5SXJqayw3Es3-MUXZrLXy5dl-vpyvkrnJwtuzn5GzdhLN1UfsuDOKV4omxyt1heHsbk9mNuZhz9zjwvngxmjPjiVM-Lnx8__Og-VxdfP33p1heVbaRIlRCE0RY5VVKKgfRMbQbDoJVUSNpSbgeQPfYUWS_5wIg0inBDOTRyo3pD2Hnx5qi7D_7PAWPSOxdt9mIm9IeoQQgmGXDFHoByQbiQckFf30O3_hCmbGSheCtBKciUOFI2-BgDDnof3M6EWQPRS2R6q-8i00tkGkDnyPLky5P-YbPD_m7uX0YZWB8BzLu7dRh0tHnpFnsX0Cbde_eAT97d01g4Z814gzPG_450pJro78vlLIcDLQGWC_sLdj6-4Q</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Vyzoukaki, Rodanthi, MD</creator><creator>Tsirakis, George, MD, PhD</creator><creator>Pappa, Constantina A., MD, PhD</creator><creator>Androulakis, Nikolaos, MSc</creator><creator>Kokonozaki, Maria, MD</creator><creator>Tzardi, Maria, MD, PhD</creator><creator>Alexandrakis, Michael G., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0003-1297-6409</orcidid><orcidid>https://orcid.org/0000-0001-8842-2360</orcidid></search><sort><creationdate>20160201</creationdate><title>Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma</title><author>Vyzoukaki, Rodanthi, MD ; Tsirakis, George, MD, PhD ; Pappa, Constantina A., MD, PhD ; Androulakis, Nikolaos, MSc ; Kokonozaki, Maria, MD ; Tzardi, Maria, MD, PhD ; Alexandrakis, Michael G., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-770325e629887f0d39bfa31582782526cf18ded2e3d86f308a906a26148b9da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiogenesis</topic><topic>Cell Count</topic><topic>Conflicts of interest</topic><topic>cytokines</topic><topic>Cytokines - metabolism</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>mast cells</topic><topic>Mast Cells - metabolism</topic><topic>Matrix Metalloproteinase 9</topic><topic>Medical Education</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - pathology</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Ribonuclease, Pancreatic - metabolism</topic><topic>Statistical analysis</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vyzoukaki, Rodanthi, MD</creatorcontrib><creatorcontrib>Tsirakis, George, MD, PhD</creatorcontrib><creatorcontrib>Pappa, Constantina A., MD, PhD</creatorcontrib><creatorcontrib>Androulakis, Nikolaos, MSc</creatorcontrib><creatorcontrib>Kokonozaki, Maria, MD</creatorcontrib><creatorcontrib>Tzardi, Maria, MD, PhD</creatorcontrib><creatorcontrib>Alexandrakis, Michael G., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Health Management</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vyzoukaki, Rodanthi, MD</au><au>Tsirakis, George, MD, PhD</au><au>Pappa, Constantina A., MD, PhD</au><au>Androulakis, Nikolaos, MSc</au><au>Kokonozaki, Maria, MD</au><au>Tzardi, Maria, MD, PhD</au><au>Alexandrakis, Michael G., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma</atitle><jtitle>Clinical therapeutics</jtitle><addtitle>Clin Ther</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>38</volume><issue>2</issue><spage>297</spage><epage>301</epage><pages>297-301</pages><issn>0149-2918</issn><eissn>1879-114X</eissn><abstract>Abstract Purpose The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors. Methods In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for tryptase and serum levels of matrix metalloproteinase 9 (MMP-9), angiopoietin 2 (ANGIOP-2), and angiogenin (ANG) with ELISA. Findings Levels of MCD, ANGIOP-2, and ANG were significantly higher in MM patients compared with the control group. The MMP-9 level was higher in MM patients compared with the control group but without statistical significance. All values were increasing in parallel with clinical stages. Furthermore, MCD correlated positively with MMP-9, ANGIOP-2, and ANG. Implications MCs participate in the angiogenic processes of MM, with complex implicated mechanisms. This interplay between MCs and the other participants favors angiogenesis and MM growth.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26740291</pmid><doi>10.1016/j.clinthera.2015.11.022</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1297-6409</orcidid><orcidid>https://orcid.org/0000-0001-8842-2360</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-2918 |
| ispartof | Clinical therapeutics, 2016-02, Vol.38 (2), p.297-301 |
| issn | 0149-2918 1879-114X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1773831693 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central |
| subjects | Aged Aged, 80 and over Angiogenesis Cell Count Conflicts of interest cytokines Cytokines - metabolism Disease Female Humans Internal Medicine Male mast cells Mast Cells - metabolism Matrix Metalloproteinase 9 Medical Education Middle Aged Multiple myeloma Multiple Myeloma - pathology Neovascularization, Pathologic - metabolism Ribonuclease, Pancreatic - metabolism Statistical analysis Tumors Vascular endothelial growth factor |
| title | Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A08%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20Mast%20Cell%20Density%20With%20Angiogenic%20Cytokines%20in%20Patients%20With%20Active%20Multiple%20Myeloma&rft.jtitle=Clinical%20therapeutics&rft.au=Vyzoukaki,%20Rodanthi,%20MD&rft.date=2016-02-01&rft.volume=38&rft.issue=2&rft.spage=297&rft.epage=301&rft.pages=297-301&rft.issn=0149-2918&rft.eissn=1879-114X&rft_id=info:doi/10.1016/j.clinthera.2015.11.022&rft_dat=%3Cproquest_cross%3E1773831693%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1766581991&rft_id=info:pmid/26740291&rft_els_id=S0149291815013181&rfr_iscdi=true |