Herpes simplex encephalitis in a captive black howler monkey (Alouatta caraya)
An 18-month-old captive black howler monkey (Alouatta caraya) died after a 3-day history of neurologic signs. Gross findings at autopsy were limited to bloody, yellow, and foul-smelling intestinal contents. Histologically, there was extensive necrotizing meningoencephalitis predominantly in both cer...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 2016-01, Vol.28 (1), p.76-78 |
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| container_title | Journal of veterinary diagnostic investigation |
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| creator | Barnes, Katie J. Garner, Michael M. Wise, Annabel G. Persiani, Michele Maes, Roger K. Kiupel, Matti |
| description | An 18-month-old captive black howler monkey (Alouatta caraya) died after a 3-day history of neurologic signs. Gross findings at autopsy were limited to bloody, yellow, and foul-smelling intestinal contents. Histologically, there was extensive necrotizing meningoencephalitis predominantly in both cerebral hemispheres, and lymphohistiocytic, neutrophilic infiltrate expanded the subarachnoid and Virchow–Robbin space. In the most severely affected regions, neurons contained eosinophilic intranuclear inclusion bodies surrounded by a clear halo and margination of the chromatin. Electron microscopy of the affected cells revealed numerous intranuclear viral particles characteristic of herpesvirus. Immunohistochemically, neurons and glial cells in the affected regions were labeled with a monoclonal antibody against Human herpesvirus 1, and was confirmed by polymerase chain reaction. |
| doi_str_mv | 10.1177/1040638715613379 |
| format | Article |
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Gross findings at autopsy were limited to bloody, yellow, and foul-smelling intestinal contents. Histologically, there was extensive necrotizing meningoencephalitis predominantly in both cerebral hemispheres, and lymphohistiocytic, neutrophilic infiltrate expanded the subarachnoid and Virchow–Robbin space. In the most severely affected regions, neurons contained eosinophilic intranuclear inclusion bodies surrounded by a clear halo and margination of the chromatin. Electron microscopy of the affected cells revealed numerous intranuclear viral particles characteristic of herpesvirus. Immunohistochemically, neurons and glial cells in the affected regions were labeled with a monoclonal antibody against Human herpesvirus 1, and was confirmed by polymerase chain reaction.</description><subject>Alouatta</subject><subject>Alouatta caraya</subject><subject>Animals</subject><subject>Diagnosis, Differential</subject><subject>Encephalitis, Herpes Simplex - diagnosis</subject><subject>Encephalitis, Herpes Simplex - veterinary</subject><subject>Herpesvirus 1, Human - isolation & purification</subject><subject>Human herpesvirus 1</subject><subject>Humans</subject><subject>Polymerase Chain Reaction - veterinary</subject><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAURS0EolDYmZDHMgT84sSOx6oCilTB0j1y7BeaNl_YCdB_T6oWBiQkpveke-4dDiFXwG4BpLwDFjHBEwmxAM6lOiJnoCIeRIqL4-Ef4mCXj8i592vG4jCWcEpGoRBKxSGckec5uhY99UXVlvhJsTbYrnRZdIWnRU01NbrtinekWanNhq6ajxIdrZp6g1s6mZZNr7tuRzm91TcX5CTXpcfLwx2T5cP9cjYPFi-PT7PpIjARhF2QYWZtZgRXEOexBpGHNmYgwpihzY2KcsGMlgjALJMAoBIAm1jQORgZ8TGZ7Gdb17z16Lu0KrzBstQ1Nr1PBzc84Szh_0EFRCIJQQ0o26PGNd47zNPWFZV22xRYuvOd_vY9VK4P631Wof0pfAsegGAPeP2K6brpXT14-XvwC48XhpA</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Barnes, Katie J.</creator><creator>Garner, Michael M.</creator><creator>Wise, Annabel G.</creator><creator>Persiani, Michele</creator><creator>Maes, Roger K.</creator><creator>Kiupel, Matti</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201601</creationdate><title>Herpes simplex encephalitis in a captive black howler monkey (Alouatta caraya)</title><author>Barnes, Katie J. ; Garner, Michael M. ; Wise, Annabel G. ; Persiani, Michele ; Maes, Roger K. ; Kiupel, Matti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-bebddbc63915f5a16f2d5016250edfc94f60ca7e110d071119811d8d1af1c743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alouatta</topic><topic>Alouatta caraya</topic><topic>Animals</topic><topic>Diagnosis, Differential</topic><topic>Encephalitis, Herpes Simplex - diagnosis</topic><topic>Encephalitis, Herpes Simplex - veterinary</topic><topic>Herpesvirus 1, Human - isolation & purification</topic><topic>Human herpesvirus 1</topic><topic>Humans</topic><topic>Polymerase Chain Reaction - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barnes, Katie J.</creatorcontrib><creatorcontrib>Garner, Michael M.</creatorcontrib><creatorcontrib>Wise, Annabel G.</creatorcontrib><creatorcontrib>Persiani, Michele</creatorcontrib><creatorcontrib>Maes, Roger K.</creatorcontrib><creatorcontrib>Kiupel, Matti</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barnes, Katie J.</au><au>Garner, Michael M.</au><au>Wise, Annabel G.</au><au>Persiani, Michele</au><au>Maes, Roger K.</au><au>Kiupel, Matti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herpes simplex encephalitis in a captive black howler monkey (Alouatta caraya)</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>2016-01</date><risdate>2016</risdate><volume>28</volume><issue>1</issue><spage>76</spage><epage>78</epage><pages>76-78</pages><issn>1040-6387</issn><eissn>1943-4936</eissn><abstract>An 18-month-old captive black howler monkey (Alouatta caraya) died after a 3-day history of neurologic signs. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SAGE Complete; Alma/SFX Local Collection |
| subjects | Alouatta Alouatta caraya Animals Diagnosis, Differential Encephalitis, Herpes Simplex - diagnosis Encephalitis, Herpes Simplex - veterinary Herpesvirus 1, Human - isolation & purification Human herpesvirus 1 Humans Polymerase Chain Reaction - veterinary |
| title | Herpes simplex encephalitis in a captive black howler monkey (Alouatta caraya) |
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