A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)
Background Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes af...
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| Veröffentlicht in: | Annals of surgical oncology 2016-03, Vol.23 (3), p.919-927 |
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| creator | Yoshida, Naohiro Kinugasa, Tetsushi Miyoshi, Hiroaki Sato, Kensaku Yuge, Kotaro Ohchi, Takafumi Fujino, Shinya Shiraiwa, Sachiko Katagiri, Mitsuhiro Akagi, Yoshito Ohshima, Koichi |
| description | Background
Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis.
Methods
The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed.
Results
A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (
p
= 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (
p
= 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (
p
= 0.04; hazard ratio [HR], 1.84; 95 % confidence interval [CI] 1.02–3.45).
Conclusions
This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC. |
| doi_str_mv | 10.1245/s10434-015-4923-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1773830452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1764339945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-7c6781db38d424acaf0e184eee8fbd9eaccac7c5b8eebd3013d026a48461f2883</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEakvLA7BBd9lKhPovicNuFCiDNFKraVhbjnOTSZWJBzsZKc_FmlfgmfBopixRF_7RyXeO7Zwoek_JJ8pEcuspEVzEhCaxyBmP-avogiZBEamkr8OepDLOWZqcR2-9fyKEZpwkZ9F5kFLBhLiIfi9g2bUbWN-v__wqb4svHNZ67Cx0HjQ8js4OLTw42w7Wj52BO21G66AJ4yEodocu4HuEx8ntu73uoRtgUe_1YLCGwvbWoRmDXBwU9xkWg-5nH9JtA0vsgx9KKLDvYTVvdxtr5hE9XJcb-hHKDTtMNAM91LDGdup1OH0-OfzNVfSm0b3Hd6f1Mvpx97UslvHq_tv3YrGKjRDZGGcmzSStKy7r8GptdEOQSoGIsqnqHLUx2mQmqSRiVXNCeU1YqoUUKW2YlPwyuj7m7pz9OaEf1bbzJlxBD2gnr2iWccmJSNgL0FRwnuciCSg9osZZ7x02aue6rXazokQdClbHglUoWB0KVjx4Ppzip2qL9T_Hc6MBYEfAh09Di0492cmFn-7_k_oX5cCxOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1764339945</pqid></control><display><type>article</type><title>A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Yoshida, Naohiro ; Kinugasa, Tetsushi ; Miyoshi, Hiroaki ; Sato, Kensaku ; Yuge, Kotaro ; Ohchi, Takafumi ; Fujino, Shinya ; Shiraiwa, Sachiko ; Katagiri, Mitsuhiro ; Akagi, Yoshito ; Ohshima, Koichi</creator><creatorcontrib>Yoshida, Naohiro ; Kinugasa, Tetsushi ; Miyoshi, Hiroaki ; Sato, Kensaku ; Yuge, Kotaro ; Ohchi, Takafumi ; Fujino, Shinya ; Shiraiwa, Sachiko ; Katagiri, Mitsuhiro ; Akagi, Yoshito ; Ohshima, Koichi</creatorcontrib><description>Background
Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis.
Methods
The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed.
Results
A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (
p
= 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (
p
= 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (
p
= 0.04; hazard ratio [HR], 1.84; 95 % confidence interval [CI] 1.02–3.45).
Conclusions
This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-015-4923-3</identifier><identifier>PMID: 26564244</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; CD3 Complex - metabolism ; CD8-Positive T-Lymphocytes - immunology ; Colorectal Cancer ; Colorectal Neoplasms - immunology ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - secondary ; Female ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - immunology ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism ; Oncology ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate ; T-Lymphocytes, Regulatory - immunology ; Th1 Cells - immunology ; Th17 Cells - immunology ; Th2 Cells - immunology ; Tissue Array Analysis</subject><ispartof>Annals of surgical oncology, 2016-03, Vol.23 (3), p.919-927</ispartof><rights>Society of Surgical Oncology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-7c6781db38d424acaf0e184eee8fbd9eaccac7c5b8eebd3013d026a48461f2883</citedby><cites>FETCH-LOGICAL-c447t-7c6781db38d424acaf0e184eee8fbd9eaccac7c5b8eebd3013d026a48461f2883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-015-4923-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-015-4923-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26564244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshida, Naohiro</creatorcontrib><creatorcontrib>Kinugasa, Tetsushi</creatorcontrib><creatorcontrib>Miyoshi, Hiroaki</creatorcontrib><creatorcontrib>Sato, Kensaku</creatorcontrib><creatorcontrib>Yuge, Kotaro</creatorcontrib><creatorcontrib>Ohchi, Takafumi</creatorcontrib><creatorcontrib>Fujino, Shinya</creatorcontrib><creatorcontrib>Shiraiwa, Sachiko</creatorcontrib><creatorcontrib>Katagiri, Mitsuhiro</creatorcontrib><creatorcontrib>Akagi, Yoshito</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><title>A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis.
Methods
The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed.
Results
A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (
p
= 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (
p
= 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (
p
= 0.04; hazard ratio [HR], 1.84; 95 % confidence interval [CI] 1.02–3.45).
Conclusions
This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor</subject><subject>CD3 Complex - metabolism</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Colorectal Cancer</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - secondary</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - immunology</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th1 Cells - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Tissue Array Analysis</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEakvLA7BBd9lKhPovicNuFCiDNFKraVhbjnOTSZWJBzsZKc_FmlfgmfBopixRF_7RyXeO7Zwoek_JJ8pEcuspEVzEhCaxyBmP-avogiZBEamkr8OepDLOWZqcR2-9fyKEZpwkZ9F5kFLBhLiIfi9g2bUbWN-v__wqb4svHNZ67Cx0HjQ8js4OLTw42w7Wj52BO21G66AJ4yEodocu4HuEx8ntu73uoRtgUe_1YLCGwvbWoRmDXBwU9xkWg-5nH9JtA0vsgx9KKLDvYTVvdxtr5hE9XJcb-hHKDTtMNAM91LDGdup1OH0-OfzNVfSm0b3Hd6f1Mvpx97UslvHq_tv3YrGKjRDZGGcmzSStKy7r8GptdEOQSoGIsqnqHLUx2mQmqSRiVXNCeU1YqoUUKW2YlPwyuj7m7pz9OaEf1bbzJlxBD2gnr2iWccmJSNgL0FRwnuciCSg9osZZ7x02aue6rXazokQdClbHglUoWB0KVjx4Ppzip2qL9T_Hc6MBYEfAh09Di0492cmFn-7_k_oX5cCxOw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Yoshida, Naohiro</creator><creator>Kinugasa, Tetsushi</creator><creator>Miyoshi, Hiroaki</creator><creator>Sato, Kensaku</creator><creator>Yuge, Kotaro</creator><creator>Ohchi, Takafumi</creator><creator>Fujino, Shinya</creator><creator>Shiraiwa, Sachiko</creator><creator>Katagiri, Mitsuhiro</creator><creator>Akagi, Yoshito</creator><creator>Ohshima, Koichi</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160301</creationdate><title>A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)</title><author>Yoshida, Naohiro ; Kinugasa, Tetsushi ; Miyoshi, Hiroaki ; Sato, Kensaku ; Yuge, Kotaro ; Ohchi, Takafumi ; Fujino, Shinya ; Shiraiwa, Sachiko ; Katagiri, Mitsuhiro ; Akagi, Yoshito ; Ohshima, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-7c6781db38d424acaf0e184eee8fbd9eaccac7c5b8eebd3013d026a48461f2883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor</topic><topic>CD3 Complex - metabolism</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Colorectal Cancer</topic><topic>Colorectal Neoplasms - immunology</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - secondary</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - immunology</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th1 Cells - immunology</topic><topic>Th17 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Tissue Array Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Naohiro</creatorcontrib><creatorcontrib>Kinugasa, Tetsushi</creatorcontrib><creatorcontrib>Miyoshi, Hiroaki</creatorcontrib><creatorcontrib>Sato, Kensaku</creatorcontrib><creatorcontrib>Yuge, Kotaro</creatorcontrib><creatorcontrib>Ohchi, Takafumi</creatorcontrib><creatorcontrib>Fujino, Shinya</creatorcontrib><creatorcontrib>Shiraiwa, Sachiko</creatorcontrib><creatorcontrib>Katagiri, Mitsuhiro</creatorcontrib><creatorcontrib>Akagi, Yoshito</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Naohiro</au><au>Kinugasa, Tetsushi</au><au>Miyoshi, Hiroaki</au><au>Sato, Kensaku</au><au>Yuge, Kotaro</au><au>Ohchi, Takafumi</au><au>Fujino, Shinya</au><au>Shiraiwa, Sachiko</au><au>Katagiri, Mitsuhiro</au><au>Akagi, Yoshito</au><au>Ohshima, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>23</volume><issue>3</issue><spage>919</spage><epage>927</epage><pages>919-927</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis.
Methods
The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed.
Results
A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (
p
= 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (
p
= 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (
p
= 0.04; hazard ratio [HR], 1.84; 95 % confidence interval [CI] 1.02–3.45).
Conclusions
This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26564244</pmid><doi>10.1245/s10434-015-4923-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2016-03, Vol.23 (3), p.919-927 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1773830452 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor CD3 Complex - metabolism CD8-Positive T-Lymphocytes - immunology Colorectal Cancer Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - secondary Female Follow-Up Studies Humans Immunoenzyme Techniques Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Oncology Prognosis Retrospective Studies Surgery Surgical Oncology Survival Rate T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Th17 Cells - immunology Th2 Cells - immunology Tissue Array Analysis |
| title | A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells) |
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