Different counteracting host immune responses to clade 2.2.1.1 and 2.2.1.2 Egyptian H5N1 highly pathogenic avian influenza viruses in naïve and vaccinated chickens

•In naïve chickens, the pathogenicity of HPAI-H5N1 correlated with IFNγ expression.•The cytokine profile was different against challenge by HPAIVs of different subclades.•In vaccinated chicken, protection correlated with IL4 expression in lung.•Efficacy of two inactivated vaccines varied against het...

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Veröffentlicht in:	Veterinary microbiology 2016-02, Vol.183, p.103-109
Hauptverfasser:	Samy, Ahmed A., El-Enbaawy, Mona I., El-Sanousi, Ahmed A., Nasef, Soad A., Naguib, Mahmoud M., Abdelwhab, E.M., Hikono, Hirokazu, Saito, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian influenza Chickens Cytokine Cytokines - immunology Egypt Gene Expression Regulation - immunology H5N1 Hemagglutinins, Viral - chemistry Hemagglutinins, Viral - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - pathogenicity Influenza in Birds - immunology Influenza in Birds - virology Influenza Vaccines - immunology Models, Molecular Poultry Diseases - immunology Poultry Diseases - virology Protein Structure, Tertiary Specific Pathogen-Free Organisms Vaccination - veterinary Vaccine Vaccines, Inactivated - immunology
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