Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

Foot-and-mouth disease virus (FMDV) capsids are often unstable, thus limiting their use as vaccines. A computational method was used to strengthen protein-protein interfaces and engineer stabilized FMDV capsids, which generated improved antibody responses in vaccinated calves and guinea pigs. Virus...

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Veröffentlicht in:	Nature structural & molecular biology 2015-10, Vol.22 (10), p.788-794
Hauptverfasser:	Kotecha, Abhay, Seago, Julian, Scott, Katherine, Burman, Alison, Loureiro, Silvia, Ren, Jingshan, Porta, Claudine, Ginn, Helen M, Jackson, Terry, Perez-Martin, Eva, Siebert, C Alistair, Paul, Guntram, Huiskonen, Juha T, Jones, Ian M, Esnouf, Robert M, Fry, Elizabeth E, Maree, Francois F, Charleston, Bryan, Stuart, David I
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/114 631/535/1258/1259 631/535/1266 692/699 Animals Antibodies Antibodies, Neutralizing - blood Base Sequence Biochemistry Biological Microscopy Calves Capsid Proteins - chemistry Capsid Proteins - metabolism Capsids Computational Biology - methods Computer applications Cryoelectron Microscopy Crystal structure Crystallography, X-Ray Design Drug Design Enzyme-Linked Immunosorbent Assay Foot & mouth disease Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - chemistry Foot-and-Mouth Disease Virus - immunology Guinea pigs Health aspects Immune response Immune system Interface stability Interfaces Life Sciences Membrane Biology Microscopy, Electron Models, Molecular Molecular biology Molecular dynamics Molecular Dynamics Simulation Molecular Sequence Data Mutation Protein Interaction Domains and Motifs Protein Structure Proteins Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Serotypes Stability analysis Structural stability Structure Vaccines Viral infections Viral vaccines Viral Vaccines - chemistry Viral Vaccines - immunology Viruses
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