The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats

•Preconditioning exercise prior to ischemia reduced infract volume and sensorimotor deficits.•MK and BDNF expression levels were upregulated by preconditioning exercise after stroke.•Preconditioning exercise activated astrocytes and promoted angiogenesis after stroke.•Preconditioning exercise reduce...

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Veröffentlicht in:	Behavioural brain research 2016-04, Vol.303, p.9-18
Hauptverfasser:	Otsuka, Shotaro, Sakakima, Harutoshi, Sumizono, Megumi, Takada, Seiya, Terashi, Takuto, Yoshida, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF Brain Ischemia - metabolism Brain Ischemia - pathology Brain-Derived Neurotrophic Factor - metabolism Caspase 3 - metabolism Cytokines - metabolism Glial Fibrillary Acidic Protein - metabolism Infarction, Middle Cerebral Artery - metabolism Male Midkine Nerve Growth Factors - metabolism Neuroprotection Oxidative stress Physical Conditioning, Animal Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Preconditioning exercise Rats Rats, Sprague-Dawley Stroke Tyrosine - analogs & derivatives Tyrosine - metabolism
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