A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF

The incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are growth factors with neuroprotective properties. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. Both GLP-1 and GIP mimetics have shown neuroprotective p...

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Veröffentlicht in:	Brain research 2016-03, Vol.1634, p.1-11
Hauptverfasser:	Ji, Chenhui, Xue, Guo-Fang, Lijun, Cao, Feng, Peng, Li, Dongfang, Li, Lin, Li, Guanglai, Hölscher, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Brain-Derived Neurotrophic Factor - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Glucagon-Like Peptide-1 Receptor - agonists Male Mice Mice, Inbred C57BL Motor Activity - drug effects Muscle Strength - drug effects Neurons - drug effects Neurons - metabolism Neuroprotective Agents - administration & dosage Parkinsonian Disorders - metabolism Parkinsonian Disorders - prevention & control Proto-Oncogene Proteins c-akt - metabolism Receptors, Gastrointestinal Hormone - agonists Rotarod Performance Test Substantia Nigra - drug effects Substantia Nigra - metabolism Tyrosine 3-Monooxygenase - metabolism
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