Pyrazinamide resistance among multidrug-resistant tuberculosis clinical isolates in a national referral center of China and its correlations with pncA , rpsA , and panD gene mutations

Abstract Our study was aimed to identify the phenotypic and genotypic pyrazinamide (PZA) resistance features among multidrug-resistant (MDR) isolates in a national tuberculosis (TB) referral center of China. PZA susceptibility test was performed for a total of 142 MDR-TB clinical isolates using the...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2016-03, Vol.84 (3), p.207-211
Hauptverfasser:	Gu, Yunting, Yu, Xia, Jiang, Guanglu, Wang, Xiaobo, Ma, Yifeng, Li, Yunxu, Huang, Hairong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Substitution Antitubercular Agents - pharmacology China - epidemiology Codon Drug Resistance, Bacterial Female Genes, Bacterial Humans Infectious Disease Internal Medicine Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Open Reading Frames pncA Promoter Regions, Genetic Pyrazinamide Pyrazinamide - pharmacology Resistance rpsA Sequence Analysis, DNA Tuberculosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology Young Adult
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