Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with intermittent bolus dosing standard therapy, despite a strong theoretical rationale for continuous administration. The aim of this trial was to determine the clinical and pharmacokinetic differences between cont...

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Veröffentlicht in:	Clinical infectious diseases 2013-01, Vol.56 (2), p.236-244
Hauptverfasser:	Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Lipman, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents ARTICLES AND COMMENTARIES Bacterial diseases Bacterial sepsis Beta lactams beta-Lactams - administration & dosage beta-Lactams - adverse effects beta-Lactams - pharmacokinetics beta-Lactams - therapeutic use Biological and medical sciences Blood plasma Boluses Clinical trials Control groups Critical care Drug dosages Drug therapy Female Hospital units Human bacterial diseases Humans Infections Infectious diseases Infusions, Intravenous Intensive care units Male Medical sciences Middle Aged Pharmacology Pharmacology. Drug treatments Sepsis Sepsis - drug therapy Sepsis - microbiology Sepsis - mortality Treatment Outcome
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