The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

A20 is a deubiquitinating enzyme that restrict inflammation by various mechanisms. Ma and colleagues show that A20 inhibits necroptosis by inhibiting the ubiquitination of RIPK3 and formation of the RIPK1-RIPK3 complex. A20 is an anti-inflammatory protein linked to multiple human diseases; however,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2015-06, Vol.16 (6), p.618-627
Hauptverfasser:	Onizawa, Michio, Oshima, Shigeru, Schulze-Topphoff, Ulf, Oses-Prieto, Juan A, Lu, Timothy, Tavares, Rita, Prodhomme, Thomas, Duong, Bao, Whang, Michael I, Advincula, Rommel, Agelidis, Alex, Barrera, Julio, Wu, Hao, Burlingame, Alma, Malynn, Barbara A, Zamvil, Scott S, Ma, Averil
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1933 631/80/82/2344 64/60 96 96/95 Animals Apoptosis Apoptosis - genetics Biomedicine Catalytic Domain - genetics Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Enzymes Fibroblasts - physiology Humans Immunology Infectious Diseases Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Jurkat Cells Medical research Medicine, Experimental Mice Mice, Inbred C57BL Mice, Knockout Multiprotein Complexes - genetics Necrosis - genetics Physiological aspects Protein Binding Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism T-Lymphocytes - physiology Tumor Necrosis Factor alpha-Induced Protein 3 Ubiquitin Ubiquitin-proteasome system Ubiquitination - genetics Ubiquitins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!