Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats

[Display omitted] •Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adre...

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Veröffentlicht in:	Behavioural brain research 2016-04, Vol.302, p.269-278
Hauptverfasser:	Kawaura, Kazuaki, Ogata, Yukino, Honda, Sokichi, Soeda, Fumio, Shirasaki, Tetsuya, Takahama, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - pharmacology Animals Antidepressive Agents - therapeutic use Antitussive Benzazepines - pharmacology Depression - drug therapy Depression - physiopathology Disease Models, Animal Dopamine Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Drug Interactions Fenclonine - pharmacology G protein-coupled inwardly rectifying potassium channel Hormones - pharmacology Imipramine - therapeutic use Immobility Response, Tonic - drug effects Locomotion - drug effects Male Piperidines - therapeutic use Rats Rats, Wistar Serotonin Antagonists - pharmacology Swimming - psychology Tipepidine Treatment-resistant depression
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